Composition variability in soy-derived dietary supplements designated for menopausal symptom prevention

BACKGROUND: Isoflavone content in soybean seeds is strongly influenced by both environment and genotype. However, little is known about the effect of environment and genotype on isoflavones in germ versus cotyledons. To determine the effect of temperature and soil moisture status during soybean seed development on seed isoflavone concentration and composition, a set of two French and three US cultivars of similar maturity were grown in the greenhouse. At the R6 growth stage, plants were subjected to one of three night/day temperature regimes (13/23• , 18/28• or 23/33• C) in either optimal or sub-optimal soil water conditions.

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Effect of temperature and water availability during late maturation of the soybean seed on germ and cotyledon isoflavone content and composition

Rasolohery

Lygin

Lozovaya

et al. 2007

J Sci Food Agric

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Comparison of analytical methods for the quality control of a new formulation containing soy extract and melatonin

Saracino

Mercolini

Musenga

et al. 2008

J of Separation Science

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Three analytical methods have been developed and compared for the quality control of a new formulation (Soymen GN(R) capsules) containing soy extract and melatonin for the treatment of menopausal symptoms. The first method is based on MEKC with diode-array detection, using a mixture of basic carbonate buffer (95%) and methanol (5%), containing 55 mM SDS, as the BGE. The second method is an HPLC method with UV detection at 260 nm. The third method is an HPLC method coupled to amperometric detection which is carried out at an oxidation potential of +0.8 V. In both HPLC systems, the chromatographic separation is obtained on an RP C18 column using a mixture of ACN and an acidic phosphate buffer (25:75 v/v) as the mobile phase. A feasible pretreatment procedure with a methanol/water mixture has been implemented to achieve the quantitative extraction of the main soy isoflavones and of melatonin from the capsules. The results obtained with the three methods are in good agreement with each other and satisfactory in terms of linearity (r(2) >0.9996), precision (RSD <5.4%) and accuracy (recovery >97%). Thus, each of the three analytical methods seems to be suitable for the simultaneous analysis of the main soy isoflavones and melatonin in the new commercial formulation.

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Characterization of isoflavone composition in soy-based nutritional supplements via ultra performance liquid chromatography

Fiechter

Raba

Jungmayr

et al. 2010

Analytica Chimica Acta

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Composition variability in soy-derived dietary supplements designated for menopausal symptom prevention

Cited by 4 publications

References 69 publications

Effect of temperature and water availability during late maturation of the soybean seed on germ and cotyledon isoflavone content and composition

Effect of temperature and water availability during late maturation of the soybean seed on germ and cotyledon isoflavone content and composition

Comparison of analytical methods for the quality control of a new formulation containing soy extract and melatonin

Characterization of isoflavone composition in soy-based nutritional supplements via ultra performance liquid chromatography

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