Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health

Hollister, Emily B.; Gao, Chunying; Versalovic, James

doi:10.1053/j.gastro.2014.01.052

Cited by 428 publications

(308 citation statements)

References 69 publications

(98 reference statements)

Supporting

Mentioning

280

Contrasting

Unclassified

Order By: Relevance

“…The complex gastrointestinal microbiota plays a pivotal role in the regulation of host physiology, and certain bacteria including Bacteroides, Bifidobacterium, Clostridium clusters XIVa and IVa, Eubacterium, Faecalibacterium, Lactobacillus, and Roseburia have been associated with gastrointestinal health [2]. As technological advances in bioinformatics, metagenomic analyses, and germ-free models have expanded our knowledge of the intestinal microbiota composition and function, this has led to the application of fecal microbiota transplantation (FMT) and intestinal microbiota therapeutics for a variety of diseases.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Clostridium difficile infection and the microbiome

2015

View full text Add to dashboard Cite

The diverse and densely populated gastrointestinal microbiota is essential for the regulation of host physiology and immune function. As our knowledge of the composition and function of the intestinal microbiota continues to expand, there is new interest in using these developments to tailor fecal microbiota transplantation (FMT) and microbial ecosystem therapeutics (MET) for a variety of diseases. The potential role of FMT and MET in the treatment of Clostridium difficile infection (CDI)-currently the leading nosocomial gastrointestinal infection-has proven highly effective for recurrent CDI, and has emerged as a paradigm shift in the treatment of this disease. The current review will serve as a summary of the key aspects of CDI, and will introduce the essential framework and challenges of FMT, as is currently practiced. MET represents the progression of conventional bacteriotherapy that fundamentally capitalizes on the restorative properties of intestinal bacterial communities and may be viewed as the culmination of a rationally designed therapeutic modality. As our understanding of the composition and function of the intestinal microbiota evolves, it will likely drive next-generation microbiota therapies for a range of medical conditions, such as inflammatory bowel disease, obesity, and metabolic syndrome.

show abstract

Section: Introductionmentioning

confidence: 99%

Recurrent Clostridium difficile infection and the microbiome

2015

View full text Add to dashboard Cite

show abstract

“…Changes in the gut microbiota composition may cause alterations in the gut barrier function and intestinal permeability, affecting not only GI epithelial cells and immune system, but also the ENS including both neurons and glial cells [51].The bidirectional brain-gut-microbiota axis interactions modulates pro-and antiinflammatory responses [52].It has been suggested that gut microbiota changes associated with intestinal inflammation may contribute to initiation of α-synmisfolding [46].There is growing number of evidence confirming that the gut microbiota alterations precede or occur during course of PD [53].However, the casual relationship between the microbiota changes and the pathogenesis of PD remains unclear [38].Gastrointestinal dysfunction in PDincludes: (a).Hypersalivation typical in PD results not from salivary hypersecretion (in fact saliva production is even diminished),but from decreased swallowing frequency. Swallowing dysfunction may be symptomatic in up to 50% of PD patients [54].…”

Section: Gut-microbiota Link In Pdmentioning

confidence: 99%

Gut-Microbiota Link in Parkinson’s Disease: Current Perspectives

Mustafa¹,

Menon²,

Mansur³

et al. 2017

IOSR JDMS

View full text Add to dashboard Cite

Abstract:Parkinson's disease(PD) is a metacentric neurodegenerative disorder results with accumulation and aggregation of alpha-synculein(α-Syn) (or alpha-synculeinopathy) Brain -gut axis(GBA) refers to central nervous system(CNS) control of the enteric nervous system(ENS) through vagus nerve intervention. PD is characterized by alphasynculeinopathy affecting all levels of the brain-gut axis.Both clinical and neuropathological evidences indicate the neurodegenerative changes in

show abstract

“…A ingestão de calorias em excesso promove a proliferação de bactérias do filo Firmicutes, que permitem a extração e estocagem de nutrientes com maior eficiência, o que auxilia no ganho de peso (4). Por outro lado, outras bactérias como Bifidobacterium, Clostridium e Bacteroides têm sido evidenciadas na melhora do metabolismo, do sistema imunitário, da resistência do câncer, da sinalização endócrina, e da função cerebral (5,6,7).…”

Section: Introductionunclassified

A Eficácia Do Tratamento Da Obesidade Através Do Transplante Da Microbiota Fecal De Indivíduos Magros

Penteado

Salgado

Barlem

2017

VITTALLE, ISSN 1413-3563, Rio Grande, Brasil

View full text Add to dashboard Cite

RESUMOHá um crescente interesse na compreensão do papel da microbiota intestinal para elucidar o seu potencial terapêutico. Uma das possíveis aplicações do transplante da microbiota fecal é no tratamento da obesidade, também denominado bacterioterapia fecal. Dessa forma, o objetivo do trabalho foi compreender o efeito terapêutico da microbiota intestinal na saúde do indivíduo. Assim como, conhecer a aplicação do transplante da microbiota fecal de indivíduos magros em indivíduos obesos. Tratou-se de uma revisão integrativa da literatura. A busca dos artigos foi realizada em abril de 2016, no Portal Regional da Biblioteca Virtual da Saúde, no período 2006-2016. Foram utilizados como critérios de inclusão: artigos disponíveis na íntegra de acesso livre; que abordaram a temática do estudo; apresentação de resumo; em língua portuguesa, inglesa ou espanhola. Dentre os descritores de ciências da saúde, utilizou-se "gastrointestinal microbiome", "fecal microbiota transplantation" e "obesity". Os artigos apresentaram como principal resultado mais encontrado que o transplante da microbiota fecal do indivíduo magro para o indivíduo obeso pode ser usado no tratamento de várias doenças tais como infecções intestinais ou em Diabetes Mellitus. Portanto, faz-se necessário a divulgação do tema em um âmbito multiprofissional facilitando o aumento de pesquisas em todas as áreas e um maior conhecimento sobre o assunto. Evidências atuais em humanos corroboram estudos em modelos animais para o tratamento da obesidade através desta técnica. Porém, os estudos ainda são escassos, dificultando a formulação de recomendações para a prática profissional. The efficacy of obesity through fecal microbiota transplantation of individuals skinnyABSTRACT -There is a growing interest in understanding the role of the intestinal microbiota to elucidate its therapeutic potential. One of the possible application of the fecal microbiota transplantation is the treatment of obesity, also called as fecal bacteriotherapy. Thus, the objective of this study was to understand the therapeutic effect of intestinal microbiota on the health of the individual. As well as, to know the application of transplantation of fecal microbiota of lean individuals in obese individuals. It was an integrative literature review.

show abstract

Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health

Cited by 428 publications

References 69 publications

Recurrent Clostridium difficile infection and the microbiome

Recurrent Clostridium difficile infection and the microbiome

Gut-Microbiota Link in Parkinson’s Disease: Current Perspectives

A Eficácia Do Tratamento Da Obesidade Através Do Transplante Da Microbiota Fecal De Indivíduos Magros

Contact Info

Product

Resources

About