“…The various alternatives involve one or more of the following steps: transforming predictors (log ratios, Box Cox transformation, Box & Cox, 1964), reducing the number of predictors to resolve the linear dependency (e.g., isometric log ratios), and/or placing constraints on regression weights to resolve the linear dependency (centered log ratios). For discussions of alternatives, see Aitchison (1982), Aitchison and Bacon-Shone (1984), Aitchison et al (2000), Chen et al (2017), Egozcue et al (2003), Greenacre and Grunsky (2019), Hron et al (2012), and Smithson and Broomell (2022). All of these alternatives suffer from a common problem: the magnitudes of the regression coefficients are difficult, if not impossible, to interpret for one or more of the following reasons.…”