2014
DOI: 10.1017/s1431927614008228
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Compositional Imaging of Cells and Bionanoparticles by EFTEM

Abstract: Elemental mapping based on electron energy loss spectroscopy (EELS) provides cell biologists with information that complements the ultrastructure obtained by conventional transmission electron microscopy (TEM) [1]. Despite the lower collection efficiency of energy filtered TEM (EFTEM) relative to spectrum-imaging in the scanning TEM (STEM) due to the EFTEM's sequential acquisition of the EELS information one energy band at a time, much higher total currents (~100 nA) are available with wide-beam illumination [… Show more

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“…In order to elucidate the mechanism of Mn uptake, rat hippocampal slices of 80 nm were imaged using a TEM first and then measured at the BNP with a photon energy above Mn k-edge. The intercellular Mn distribution was then correlated with the TEM ultrastructure [5]. SXFM delivers unprecedented elemental sensitivity, which well complements the higher spatial resolution offered by TEM.…”
mentioning
confidence: 99%
“…In order to elucidate the mechanism of Mn uptake, rat hippocampal slices of 80 nm were imaged using a TEM first and then measured at the BNP with a photon energy above Mn k-edge. The intercellular Mn distribution was then correlated with the TEM ultrastructure [5]. SXFM delivers unprecedented elemental sensitivity, which well complements the higher spatial resolution offered by TEM.…”
mentioning
confidence: 99%