A fIelD experiment was conducted at the experimental farm of Soil and Water Research Department, Nuclear Research Centre, Atomic energy Authority, Inshas, egypt to investigate the effects of radiating canola seeds with γ-ray at three doses, i.e. 100, 200 and 300 Gy vs the non-irradiated controlon plant growth performance and yield productivity. Nitrogen fertilization and the source of irrigation water were also matters of concern in this study. All experimental plots received the recommended dose of N-fertilizers (150 kg N ha-1) in either of the following forms:100% mineral-N, 100% organic-N or 50% mineral-N +50% organic-N. Also, a drip irrigation-system was constructed to irrigate canola plants with either freshwater or treated-wastewater. Irradiation, in general, resulted in higher values of canola-dry-weights which were enhanced by increasing gamma ray dose up to 300Gy. Similarly, NPK contents within different plant parts of the irradiated-canola increased in an order coincide with the magnitudes of the used irradiation dose, i.e. 300Gy> 200Gy >100Gy > 0Gy. Moreover, oil yield was significantly increased with increasing gamma dose. On the other hand, the enhancement of NPK uptake was more vigorous in case of combined-fertilization-treatment (50% mineral-N +50% organic-N) than the application of either 100% mineral-N or 100% organic-N. This consequently raised significantly root and shoot dry weights as well as seed yield and canola oil productivity. It seems that irrigation with treated wastewater resulted in higher increases in NPK uptake as well as canola oil yield than irrigation with freshwater. Thus, it can be deduced that the combined-fertilization-treatment and high irradiation dose of gamma-ray had achieved the highest increases in plant DW and productivity (5.3 Mg seed yield ha-1), at the same time these values were higher under irrigation with treated wastewater than those irrigated with fresh water.