Compostos fenólicos da casca de Handroanthus heptaphyllus (Mart.) Mattos e efeitos do extrato aquoso no perfil lipídico, glicêmico e na lipoperoxidação em ratos diabéticos

Abstract

Compostos fenólicos da casca de Handroanthus heptaphyllus (Mart.) MattosABSTRACT: Phenolic compounds from Handroanthus heptaphyllus (Mart.) Mattos bark and effects of aqueous extract on lipid profile, glucose, and lipid peroxidation in diabetic rats. Alternative medicine for diabetes mellitus (DM) treatment represents a growing research area on the use of medicinal plants, of which Handroanthus heptaphyllus (mart.) Mattos (popularly known as purple ipe) is most prominent. In this study, we investigated the presence of phenolic compounds and the effects of treatment with aqueous extract of in H. heptaphyllus in biochemical profile in plasma and the levels of lipid peroxidation in tissues and plasma in diabetic animals. Male Wistar rats were induced to develop DM through intraperitoneal (IP) administration of alloxan monohydrate (150 mg/kg IP). Once hyperglycemia (>200 mg dL-1) was confirmed, the animals were divided into the Diabetic (D; n=6) and Treated Diabetic (TD; n=6) groups. The TD group received daily administration (150 mg/kg v.o.) of aqueous extract of H. heptaphyllus for four weeks. The aqueous extract was also analyzed qualitatively by layer chromatography. Qualitative analysis of the aqueous extract of the bark indicated the presence of phenolic compounds from the flavonoid subclass. The treatment with the aqueous extract reduced fasting blood glucose levels from the third week of treatment on, improved the glycemic response to the glucose tolerance test, and lowered the levels of triglycerides and the LDL

Pfaffia glomerata: Gallic acid and phenolic compounds determination

“…The fraction AcOEt and the gallic acid standard, under UV 264 nm light, showed fluorescence because of the chromophore group present in this phenol (Grochanke, 2016), besides having the same retention time, under the same conditions, fact that point the gallic acid presence in the fraction. The phenolic compounds content in fraction CHCl3 was smaller (70.3 mg/g) than in fraction AcOEt (118.6 mg/g).…”

Atividade do extrato hidroetanólico das folhas de Raphanus Sativus em glândulas submandibulares de ratos com diabetes mellitus

“…Alguns estudos mostram que o efeito hipoglicêmico do rabanete está atrelado a melhora da sensibilidade ou exercendo atividade semelhante à insulina devido a um componente antioxidante responsável pelo efeito que estimula as células β pancreáticas a liberarem mais insulina (Borba et al, 2006& Taniguchi et al, 2006. Outros compostos antioxidativos observados no extrato como compostos fenólicos, presença de flavonoide e vitamina E facilitam a entrada de glicose na célulaalvo (Banihani, 2017;Grochanke et al, 2016;Rocha Navarro et al, 2019;Taniguchi et al, 2006).…”

AVALIAÇÃO DO POTENCIAL HIPOGLICEMIANTE DO EXTRATO DE BACUPARI (Salacia elliptica) EM CAMUNDONGOS DIABÉTICOS

“…O estudo conduzido por Grochanke et al (2016) evidencia que a adoção de tratamentos terapêuticos alternativos, baseados no uso de plantas medicinais, está emergindo como uma estratégia viável para a prevenção de doenças crônicas, notadamente o Diabetes. A medicina Ayurveda, praticada no Sri Lanka e na Índia, recomenda o uso das raízes e caules de Salácia oblonga e Salácia reticulata como um meio de prevenir o Diabetes em seu estágio inicial.…”