Compound allergy

Abstract

This review defines the term "compound allergy" in the context of new findings, and discusses evidence that allergenic reaction products have been identified. Material was gathered by searching Index Medicus and the Science Citation Index, and reviewing several standard texts. Issues regarding the validity of patch test results are addressed and we introduce the term "pseudocompound allergy" to cover cases of false-negative patch tests. We present new theories regarding the mechanisms by which new allergens are formed and a means of classification.

Should carba mix be reintroduced into the European baseline series?

“…In total, 17% of patients with isolated carba mix sensitization had positive reactions to at least one of the three ingredients in the mix, and 34% had doubtful reactions. False-positive reactions to carba mix occur, but some of the missing positive reactions to the constituents of carba mix could be explained by pseudo-compound allergy (comparing patch test results obtained with different vehicles) (5). Furthermore, there is a need for studies testing carba mix together with all three ingredients separately to re-evaluate the reliability of the mix and establish the optimal test concentration for the mixture and for the individual ingredients.…”

Allergic Contact Dermatitis from Cosmetics

“…30-45% [21]. The 8 patients who reacted only to their own products may be explained by the fact that they contained allergens that were not tested (the cosmetic industry uses thousands of molecules) [3,7] or that there was a compound allergy [22]. This emphasizes that testing the patients' own products remains substantial and that [23,24].…”

Cradle-to-cradle design: creating healthy emissions – a strategy for eco-effective product and system design

“…Even more, existing knowledge about the toxicity of substances is for the most part limited to the toxicity of single substances. Studies show that significant allergenic potential also exists in synergies amongst multiple chemicals [15]. This presents an especially increased risk in the context of products that employ a larger set of chemicals and chemical combinations.…”