Compound gonadotrophic pituitary adenoma and rhabdomyosarcoma

Silva, Ana Cristina Araujo Lemos de; Rodríguez, Fausto J.; Aldecoa, Ibán; McDonald, William C.; Ribalta, Teresa

doi:10.1111/his.12890

Cited by 5 publications

(3 citation statements)

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“…Thus, it is more likely of a pituitary sarcoma arising from the adenoma rather than a radiation-induced tumor. As proposed by de Silva et al., this may potentially be a metaplastic transformation from the pituitary adenoma or two independent lesions, with the RMS originating from primitive mesenchymal in the dura mater of the sellar floor or in pericapillary space of the pituitary gland ( 5 , 6 ). Another interesting finding is the presence of multiple genetic mutations in the tumor.…”

Section: Discussionmentioning

confidence: 96%

“…Sellar RMS have been mostly reported in association with radiation for pituitary tumors (1,2). Though rare, there are a few reported cases of pituitary RMS arising from pituitary adenoma without any prior therapy (3)(4)(5)(6). It has been suggested in the literature that the median latency period between radiotherapy and tumor occurrence is 10.5 years (7).…”

Section: Introductionmentioning

confidence: 99%

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Molecular Profile of a Pituitary Rhabdomyosarcoma Arising From a Pituitary Macroadenoma: A Case Report

Chen

2021

Front. Endocrinol.

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Pituitary sarcoma arising in association with pituitary adenoma is an uncommon finding. Most cases of secondary sarcoma have been noted to arise with a median interval of 10.5 years post radiation. In this case report, we describe a 77-year-old man with an incidental discovery of a pituitary macroadenoma on magnetic resonance imaging (MRI) and underwent radiotherapy. Three years after radiation treatment, there was an acute change in clinical symptoms and increase in tumor size and mass effect on the optic chiasm which prompted surgical resection. A pituitary adenoma along with a separate spindle-cell sarcomatous component was identified in histology. Immunohistochemical stain for muscle markers confirmed a development of pituitary rhabdomyosarcoma (RMS). Molecular profiling of the tumor identified mutations in TP53, ATRX, LZTR1, and NF1. Despite its rarity, characterization of pituitary RMS with immunohistochemistry and molecular studies may provide an insight to its pathophysiological relationship with pituitary adenoma.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Molecular Profile of a Pituitary Rhabdomyosarcoma Arising From a Pituitary Macroadenoma: A Case Report

Chen

2021

Front. Endocrinol.

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“…de Silva AC et al reported a case of combined gonadotrophic pituitary tumor and rhabdomyosarcoma. They maintained two possibilities of the etiology of the rhabdomyosarcomatous component: metaplastic transformation from a pituitary adenoma or independent collision tumors [4] . Virginia E. et al advocated a serious suspicion for coexistent rhabdomyosarcoma with pituitary adenoma in cases of atypical pituitary adenoma with a stromal response [5] .…”

Section: Discussionmentioning

confidence: 99%

Collision Occurrence of Sinonasal Carcinosarcoma and Pituitary Adenoma: A Case Report and Literature Review.

Liu

Yang

Zhang

et al. 2020

Preprint

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BACKGROUND: Collision occurrences of sinonasal carcinosarcoma and pituitary adenoma are rarely reported. Sinonasal carcinosarcomas represent rare neoplasms with invasive characteristics and unfavorable prognoses.CASE DESCRIPTION: We present a rare case of a collision occurrence of sinonasal carcinosarcoma and pituitary adenoma in a 45‐year‐old male patient. MRI demonstrated a large mass involving the sellar region, nasal cavity, paranasal sinuses and anterior cranial base. Total surgical resection with a pure endoscopic expanded endonasal approach was performed successfully with neuronavigational assistance. Histopathologic results were a carcinosarcoma in the nasal cavity, paranasal sinuses, and anterior cranial base and a pituitary adenoma in the intrasellar zone. The Ki-67 index of the carcinosarcoma was high (more than 95%). Although the patient received chemotherapy, he died 6 months after surgery because of in situ recurrence and extensive metastatic growth.CONCLUSIONS: Collision occurrences of sinonasal carcinosarcoma and pituitary adenoma are rare events. Such tumor could be removed successfully by neuronavigational guidance with a pure endoscopic expanded endonasal approach. A contralateral nasal septum mucosa flap without tumor invasion can be used as a kind of skull base repair material. A high Ki-67 index may be a biomarker of rapid tumor progression and poor prognosis in such patients.

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