Compound heterozygous protein C deficiency with pulmonary embolism caused by a novel PROC gene mutation: Case report and literature review

Zhang, Zhaorui; Yang, Zhen; Chen, Mei; Li, Yuzhu

doi:10.1097/md.0000000000031221

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…ROC analysis was conducted using the R package pROC (version 1.17.0.1) [11] to calculate the area under the curve (AUC). Genes with a higher degree value were selected for the ROC analysis, and those with an AUC of ≥ 0.70 were considered to have signi cant clinical diagnostic potential.…”

Section: Establishment and Calculation Of Roc Curvementioning

confidence: 99%

Exploring the ceRNA Network of Differentially Expressed lncRNAs in Gout: A Bioinformatics Analysis

Guo

Peng

et al. 2023

Preprint

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Objective: To elucidate the regulatory mechanisms of the competing endogenous RNA (ceRNA) network associated with gout, and to investigate potential targets for diagnosis and treatment of this disease. Methodology: The GSE160170 dataset was downloaded from the GEO database, annotated, and gene attributes were added. Differential expression of lncRNAs and mRNAs between gout patients and non-gout patients was analyzed using R software. The miRNAs targeted by differentially expressed lncRNAs and mRNAs were predicted, and a lncRNA-miRNA-mRNA network was constructed to analyze the competing relationships between lncRNAs and mRNAs. Functional enrichment analysis was performed to investigate the molecular functions of mRNAs regulated by lncRNAs in the ceRNA network. Key mRNAs were identified by constructing protein-protein interaction (PPI) networks and ROC curves, and their diagnostic efficacy was evaluated. Results: Ten differential lncRNAs were identified and analyzed using the ceRNA approach. Functional enrichment analysis showed that the mRNA regulated by differential lncRNAs was significantly enriched in protein phosphatase, DNA transcription factor binding activity, TNF pathway, and toll-like receptor-related pathway. Among the seven mRNAs with high diagnostic value identified through PPI and ROC curve analysis were BTG2, FOS, GATA2, JUN, MAPK6, and NAR4, which were the core genes of this study and have the potential to be used as diagnostic and therapeutic targets for gout. Additionally, five lncRNAs, including FAM182A, UCA1, MIR22HG, TTY10, and FAM215B, affected the expression of key mRNAs by adsorbing miRNAs such as hsa-miR-27a-3p and hsa-miR-1297, which may play a crucial role in the pathogenesis of gout.

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Section: Establishment and Calculation Of Roc Curvementioning

confidence: 99%

Exploring the ceRNA Network of Differentially Expressed lncRNAs in Gout: A Bioinformatics Analysis

Guo

Peng

et al. 2023

Preprint

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Numerical simulation and in vitro experimental study of the hemodynamic performance of vena cava filters with helical forms

Huang,

Li,

Liu

et al. 2024

Sci Rep

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Inferior vena cava filter (IVCF) implantation is a common method of thrombus capture. By implanting a filter in the inferior vena cava (IVC), microemboli can be effectively blocked from entering the pulmonary circulation, thereby avoiding acute pulmonary embolism (PE). Inspired by the helical flow effect in the human arterial system, we propose a helical retrievable IVCF, which, due to the presence of a helical structure inducing a helical flow pattern of blood in the region near the IVCF, can effectively avoid the deposition of microemboli in the vicinity of the IVCF while promoting the cleavage of the captured thrombus clot. It also reduces the risk of IVCF dislodging and slipping in the vessel because its shape expands in the radial direction, allowing its distal end to fit closely to the IVC wall, and because its contact structure with the inner IVC wall is curved, increasing the contact area and reducing the risk of the vessel wall being punctured by the IVCF support structure. We used ANSYS 2023 software to conduct unidirectional fluid-structure coupling simulation of four different forms of IVCF, combined with microthrombus capture experiments in vitro, to explore the impact of these four forms of IVCF on blood flow patterns and to evaluate the risk of IVCF perforation and IVCF dislocation. It can be seen from the numerical simulation results that the helical structure does have the function of inducing blood flow to undergo helical flow dynamics, and the increase in wall shear stress (WSS) brought about by this function can improve the situation of thrombosis accumulation to a certain extent. Meanwhile, the placement of IVCF will change the flow state of blood flow and lead to the deformation of blood vessels. In in vitro experiments, we found that the density of the helical support rod is a key factor affecting the thrombus trapping efficiency, and in addition, the contact area between the IVCF and the vessel wall has a major influence on the risk of IVCF displacement.

show abstract

Numerical simulation and in vitro experimental study of the hemodynamic performance of vena cava filters with helical forms

Huang,

Li,

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

Inferior vena cava filter (IVCF) implantation is a common method of thrombus capture. By implanting a filter in the inferior vena cava (IVC), microemboli can be effectively blocked from entering the pulmonary circulation, thereby avoiding acute pulmonary embolism (PE). Inspired by the helical flow effect in the human arterial system, we propose a helical retrievable IVCF, which, due to the presence of a helical structure inducing a helical flow pattern of blood in the region near the IVCF, can effectively avoid the deposition of microemboli in the vicinity of the IVCF while promoting the cleavage of the captured thrombus clot. It also reduces the risk of IVCF dislodging and slipping in the vessel because its shape expands in the radial direction, allowing its distal end to fit closely to the IVC wall, and because its contact structure with the inner IVC wall is curved, increasing the contact area and reducing the risk of the vessel wall being punctured by the IVCF support structure. We used Ansys Fluent software to conduct unidirectional fluid-structure coupling simulation of four different forms of IVCF, combined with microthrombus capture experiments in vitro, to explore the impact of these four forms of IVCF on blood flow patterns and to evaluate the risk of IVCF perforation and IVCF dislocation. It can be seen from the numerical simulation results that the helical structure does have the function of inducing blood flow to undergo helical flow dynamics, and the increase in wall shear stress (WSS) brought about by this function can improve the situation of thrombosis accumulation to a certain extent. Meanwhile, the placement of IVCF will change the flow state of blood flow and lead to the deformation of blood vessels. In in vitro experiments, we found that the density of the helical support rod is a key factor affecting the thrombus trapping efficiency, and in addition, the contact area between the IVCF and the vessel wall has a major influence on the risk of IVCF displacement.

show abstract

Compound heterozygous protein C deficiency with pulmonary embolism caused by a novel PROC gene mutation: Case report and literature review

Cited by 3 publications

References 33 publications

Exploring the ceRNA Network of Differentially Expressed lncRNAs in Gout: A Bioinformatics Analysis

Exploring the ceRNA Network of Differentially Expressed lncRNAs in Gout: A Bioinformatics Analysis

Numerical simulation and in vitro experimental study of the hemodynamic performance of vena cava filters with helical forms

Numerical simulation and in vitro experimental study of the hemodynamic performance of vena cava filters with helical forms

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