Compound Identification in Thin-Layer Chromatography Using Spectrometric Methods

Gocan, Simion; Cîmpan, Gabriela

doi:10.1515/revac.1997.16.1.1

Cited by 11 publications

(2 citation statements)

References 98 publications

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“…Thin-layer chromatographic separation of various mixtures coupled with Raman detection has been successfully demonstrated in a number of applications. [11][12][13][14][15] Similarly, we have tested a simple method for analyzing impure street samples that involves an initial separation of components on a TLC plate followed by a Raman measurement. The R f values for each separated drug were determined after visualizing the separated spots by blowing a stream of gaseous iodine across the surface of the TLC plate.…”

Section: Resultsmentioning

confidence: 99%

Raman Spectroscopy for the in Situ Identification of Cocaine and Selected Adulterants

2000

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We demonstrate the in situ identi cation of crack cocaine and cocaine•HC l by using a ber-optic Raman probe and a portable Raman spectrograph. The Raman spectru m of freebase cocaine (crack) is obtained in just seconds without any sample preparation, and differs signi cantly from that of cocaine•HCl. We also show that the Raman spectra of these drugs are easily distinguishable from comm on cutting agents and impurities such as benzocaine and lidocaine. Another advantage of using Raman spectroscop y is that the drugs can be identi ed while contained in transparent containers, such as clear plastic evidence containers that are used to store drug evidence and to maintain chain of custody. W e also demonstrate the in situ Raman identi cation of drugs separated by thinlayer chrom atography. We discuss the utility of surface-enhanced Raman spectroscopy (SERS) in toxicological drug screen ing and present prelim inary SERS data for cocaine in solution using colloidal silver. We believe this to be the rst published SERS spectru m of freebase cocaine.

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Section: Resultsmentioning

confidence: 99%

Raman Spectroscopy for the in Situ Identification of Cocaine and Selected Adulterants

2000

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“…More characteristic information on the compounds is obtained by coupling TLC with more selective detection techniques, such as Raman spectrometry, infrared spectrometry (IR), or mass spectrometry (MS). [10,11] Identification of the separated components of a mixture by purely chromatographic characteristics cannot be done unequivocally, thus the demand for spectroscopic fingerprinting in order to increase the reliability of the analysis is highly justified. The vibrational spectrometric techniques provide a useful alternative for compounds separated by TLC.…”

Section: Introductionmentioning

confidence: 99%

Separation and Identification of Eight Hydrophilic Vitamins Using a New TLC Method and Raman Spectroscopy

Cimpoiu

Casoni

Hosu

et al. 2005

Journal of Liquid Chromatography & Related Technologies

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Hydrophilic vitamins play an important role in human health. The analysis of these compounds is indispensable for monitoring their content in pharmaceuticals and food in order to prevent some human diseases. The separation and identification of eight hydrophilic vitamins, i.e., B 1 , B 2 , B 3 , B 5 , B 6 , B 9 , B 12 , and C, was achieved by thin layer chromatography and Raman spectrometry. After chromatographic experiments, the best results were obtained using programmed multiple development. The unambiguous identification of superimposed spots can be done without using standards of vitamins.

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HPTLC Hyphenated with FTIR: Principles, Instrumentation and Qualitative Analysis and Quantitation

Cimpoiu

2010

High-Performance Thin-Layer Chromatography (HPTLC)

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Compound Identification in Thin-Layer Chromatography Using Spectrometric Methods

Cited by 11 publications

References 98 publications

Raman Spectroscopy for the in Situ Identification of Cocaine and Selected Adulterants

Raman Spectroscopy for the in Situ Identification of Cocaine and Selected Adulterants

Separation and Identification of Eight Hydrophilic Vitamins Using a New TLC Method and Raman Spectroscopy

HPTLC Hyphenated with FTIR: Principles, Instrumentation and Qualitative Analysis and Quantitation

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