Global warming may increase potential evapotranspiration (ETp), reducing the water resources in Yangzi River Delta. Therefore, it is important to investigate the trend of ETp there under the background of climate change. To this purpose, the systematic biases in temperature outputs of 24 global climate models (GCMs) under 3 shared socioeconomic pathways—representative concentration pathways (SSPs) emission scenarios (SSP1-2.6, SSP2-4.5, and SSP5-8.5)—are first corrected by using 8 bias correction methods. Then, the trend of ETp in Yangtze River Delta is projected by using 4 ETp calculation formulas (Blaney–Criddle, Hargreaves–Samani, Makkink, and Priestley–Taylor). The uncertainty of the projections is estimated and decomposed by using multi-way analysis of variance frameworks. The influence of uncertainty on the projected change signal is quantified by using the signal-to-noise ratio. The results show that all emission scenarios indicate robust increments of ETp. Specifically, relative to 1971~2000, ETp will increase by 0.14~0.17 mm d−1 (5.7~6.8%) during 2021~2050 and by 0.21~0.41 mm d−1 (8.5~16.7%) during 2061~2090, respectively. During 2021~2050, the uncertainty of ETp projections is dominantly contributed by the main effects of GCM (63%) and the ETp calculation formula (24%). During 2061~2090, it is mainly contributed by the main effect of GCM (36%), followed by the main effects of the emission scenario (34%) and the ETp calculation formula (18%). The ETp projections are generally reliable and robust during the two projection periods.