Comprehensive analysis of 7-methylguanosine and immune microenvironment characteristics in clear cell renal cell carcinomas

Abstract

Clear cell renal cell carcinoma (ccRCC) is one of the most common tumors in the urinary system. ccRCC has obvious immunological characteristics, and the infiltration of immune cells is related to the prognosis of ccRCC. The effect of immune checkpoint therapy is related to the dynamic changes of the tumor immune microenvironment (TIM). The 7-methylguanosine (m7G) is an additional mRNA modification ability besides m6A, which is closely related to the TIM and affects the occurrence and development of tumors. At present, the correlations between m7G and the immune microenvironment, treatment, and prognosis of ccRCC are not clear. As far as we know, there was no study on the relationship between m7G and the immune microenvironment and survival of clear cell renal cell carcinomas. A comprehensive analysis of the correlations between them and the construction of a prognosis model are helpful to improve the treatment strategy. Two different molecular subtypes were identified in 539 ccRCC samples by describing the differences of 29 m7G-related genes. It was found that the clinical features, TIM, and prognosis of ccRCC patients were correlated with the m7G-related genes. We found that there were significant differences in the expression of PD-1, CTLA4, and PD-L1 between high- and low-risk groups. To sum up, m7G-related genes play a potential role in the TIM, treatment, and prognosis of ccRCC. Our results provide new findings for ccRCC and help to improve the immunotherapy strategies and prognosis of patients.

Molecular characterization, clinical value, and cancer–immune interactions of genes related to disulfidptosis and ferroptosis in colorectal cancer

“…The risk score was computed via genes linked to prognosis, i.e., SRGs and FRGs. However, no prior studies The expression level of PD-L1 and CTLA-4 was remarkably elevated in the low-risk category relative to the highrisk category, congruent with literature findings [44,45]. ICIs are common immunomodulatory monoclonal antibodies.…”

Biochemical Profiling of Urine Metabolome in Premature Infants Based on LC−MS Considering Maternal Influence

“…According to previous research, high urinary hypoxanthine levels can be related to respiratory disorders and deficiencies in hypoxanthine-guanine phosphoribosyltransferase to acute renal failure in infants [52,53]. Additionally, 7−methylguanosine, the modified purine nucleoside, showed significant VIP scores, associated with ischemic diseases and identified as a biomarker in cancer studies [54,55]. In brief, these upregulations suggest significant metabolic mechanisms related to kidney and respiratory development.…”

m7G Methylation-Related Genes Impact Prognosis and Tumor Immune Microenvironment in bladder cancer

“…A large number of studies indicate that METTL1 is upregulated in solid tumors, which often predict poor survival (13). Some studies also have shown that m7G-related genes(EIF3D, EIF4E1B, LARP1, NCBP1, GEMIN5, and DCP2) are associated with the progression of tumors as well as the prognosis of patients (14,15,16). In Bca, whether m7G can regulate the occurrence and development of tumors, and how M7G key genes and related gene expressions are still unknown Tumor microenvironment (TME) is a complex system with various stromal cells, such as broblasts, vascular endothelial cells, immune cells, adipocytes, mesenchymal stem cells, and various cytokines (17).…”