Cardiospermum halicacabum L., a notable species of the genus Cardiospermum, is well-known for its culinary and medicinal properties. Nonetheless, a detailed description of the C. halicacabum chloroplast's phylogeny and genes is still absent. We present the findings of an in-depth investigation of the chloroplast genome of C. halicacabum. The circular, 159,370 bp chloroplast genome of C. halicacabum has a 37.91% GC content. There are 134 genes in the circular genome, comprising 89 protein-coding genes, 37 tRNAs, and 8 rRNAs. There are found to be 28 simple sequence repeats. Comparative chloroplast genome analysis of five related species suggests that Between C. halicacabum and other Sapindaceae species, there are variations in the contraction and extension of the reverse repeat region. Our phylogenetic analysis illustrates C. halicacabum has a relatively close relationship with S. erecta. The chloroplast genome of C. halicacabum has been examined, advancing our understanding of the evolutionary relationships among Sapindaceae.