Residual film pollution and excessive nitrogen fertilizer have become limiting factors for agricultural development. To investigate the feasibility of replacing conventional plastic film with biodegradable plastic film in cold and arid environments under nitrogen application conditions, field experiments were conducted from 2021 to 2022 with plastic film covering (including degradable plastic film (D) and ordinary plastic film (P)) combined with nitrogen fertilizer 0 (N0), 160 (N1), 320 (N2), and 480 (N3) kg·ha−1. The results showed no significant difference (p > 0.05) in dry matter accumulation, photosynthetic gas exchange parameters, soil enzyme activity, or yield of spring maize under degradable plastic film cover compared to ordinary plastic film cover. Nitrogen fertilizer is the main factor limiting the growth of spring maize. The above-ground and root biomass showed a trend of increasing and then decreasing with the increase in nitrogen application level. Increasing nitrogen fertilizer can also improve the photosynthetic gas exchange parameters of leaves, maintain soil enzyme activity, and reduce soil pH. Under the nitrogen application level of N2, the yield of degradable plastic film and ordinary plastic film coverage increased by 3.74~42.50% and 2.05~40.02%, respectively. At the same time, it can also improve water use efficiency and irrigation water use efficiency, but it will reduce nitrogen fertilizer partial productivity and nitrogen fertilizer agronomic use efficiency. Using multiple indicators to evaluate the effect of plastic film mulching combined with nitrogen fertilizer on the comprehensive growth of spring maize, it was found that the DN2 treatment had the best complete growth of maize, which was the best model for achieving stable yield and income increase and green development of spring maize in cold and cool irrigation areas.