2017
DOI: 10.1038/nprot.2017.032
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Comprehensive analysis of mouse retinal mononuclear phagocytes

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Cited by 51 publications
(51 citation statements)
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References 55 publications
(78 reference statements)
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“…When the blood‐retinal barrier is compromised, microglia infiltrate the subretinal space with their protrusions. These cells become ameboid phagocytes that can produce a variety of inflammatory mediators, including ROS and cytokines (Luckoff et al, ; Madeira, Boia, Santos, Ambrosio, & Santiago, ).VEGF receptor blockade reduced retinal microglia/macrophage infiltration in laser‐induced CNV (Huang, Parlier, Shen, Lutty, & Vinores, ). In our study, B 1 receptors were party colocalized with microglia, close to the experimental laser spots, particularly in the choroid.…”
Section: Discussionmentioning
confidence: 99%
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“…When the blood‐retinal barrier is compromised, microglia infiltrate the subretinal space with their protrusions. These cells become ameboid phagocytes that can produce a variety of inflammatory mediators, including ROS and cytokines (Luckoff et al, ; Madeira, Boia, Santos, Ambrosio, & Santiago, ).VEGF receptor blockade reduced retinal microglia/macrophage infiltration in laser‐induced CNV (Huang, Parlier, Shen, Lutty, & Vinores, ). In our study, B 1 receptors were party colocalized with microglia, close to the experimental laser spots, particularly in the choroid.…”
Section: Discussionmentioning
confidence: 99%
“…The total number of ameboid and ramified‐shaped microglial cells marked with Iba1 was counted within a circular region of 200‐μm diameter adjacent to the CNV in retinal sections (Luckoff, Scholz, Sennlaub, Xu, & Langmann, ). Cellular morphology was analysed using a grid system to determine the number of grid cross per cell (Chen et al, ).…”
Section: Methodsmentioning
confidence: 99%
“…Circularity was calculated by the following formula: 4π × (area/perimeter 2 ). Ramification index of Iba1 + and GFAP + cells were quantified by gridcross analysis using the ImageJ 1.46r (http://imagej.nih.gov/ ij/download.html) [33,34]. Briefly, a grid was overlaid by images of the CA1, CA3, and DG regions.…”
Section: Immunohistochemistry and Analysismentioning
confidence: 99%
“…The grid-crossed point analysis was used to quantify CX3CR1 + cells ramification, per published guidelines (34)(35)(36). Briefly, the "grid function" in ImageJ version 1.5s was used to perform the analysis.…”
Section: Quantification Of Cx3cr1 + Cell Morphology Using Grid Analysismentioning
confidence: 99%