2023
DOI: 10.1111/his.14871
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Comprehensive analysis of SARS‐CoV‐2 receptor proteins in human respiratory tissues identifies alveolar macrophages as potential virus entry site

Abstract: Comprehensive analysis of SARS-CoV-2 receptor proteins in human respiratory tissues identifies alveolar macrophages as potential virus entry site Aims: COVID-19 has had enormous consequences on global health-care and has resulted in millions of fatalities. The exact mechanism and site of SARS-CoV-2 entry into the body remains insufficiently understood. Recently, novel virus receptors were identified, and alveolar macrophages were suggested as a potential viral entry cell type and vector for intra-alveolar viru… Show more

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Cited by 2 publications
(1 citation statement)
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“…Interestingly, Kringle containing transmembrane protein 1 (KREMEN1) is a transmembrane receptor involved in WNT signalling that has recently been proposed as an alternative receptor for the SARS-CoV-2 virus 22 . KREMEN1 is a known entry receptor for enteroviruses, such as coxsackievirus A10, and is expressed at potential virus entry sites (i.e., sinonasal, conjunctival and bronchiolar epithelium) 44,45 . In blood, KREMEN1 expression is mainly restricted to leucocytes, including neutrophils, monocytes, T cells and B cells.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, Kringle containing transmembrane protein 1 (KREMEN1) is a transmembrane receptor involved in WNT signalling that has recently been proposed as an alternative receptor for the SARS-CoV-2 virus 22 . KREMEN1 is a known entry receptor for enteroviruses, such as coxsackievirus A10, and is expressed at potential virus entry sites (i.e., sinonasal, conjunctival and bronchiolar epithelium) 44,45 . In blood, KREMEN1 expression is mainly restricted to leucocytes, including neutrophils, monocytes, T cells and B cells.…”
Section: Discussionmentioning
confidence: 99%