Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryote
Alexei Yu. Kostygov,
Karolína Skýpalová,
Natalia Kraeva
et al.
Abstract:Background
In trypanosomatids, a group of unicellular eukaryotes that includes numerous important human parasites,
cis
-splicing has been previously reported for only two genes: a poly(A) polymerase and an RNA helicase. Conversely,
trans
-splicing, which involves the attachment of a spliced leader sequence, is observed for nearly every protein-coding transcript. So far, our understanding of splicing in this protistan group has stemmed from the … Show more
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