Comprehensive Analysis of the PRDXs Family in Head and Neck Squamous Cell Carcinoma

Abstract

The peroxidase family of peroxiredoxins (PRDXs) plays a vital role in maintaining the intracellular balance of ROS. However, their function in head and neck squamous cell carcinoma (HNSCC) has not been investigated. We therefore explored the value of PRDXs in HNSCC. We found that the expression of PRDX1, PRDX4, and PRDX5 in HNSCC increased while the expression of PRDX2 decreased. Moreover, the high expression of PRDX4/5/6 indicated a poor prognosis. Lower expression of PRDX1/5 was linked to more immune cell infiltration, higher expression of immune-related molecules and a more likely response to anti-PD-1 treatment. Moreover, PRDX5 knockdown inhibited HNSCC cell proliferation, invasion and metastasis and it might promote apoptosis through its antioxidant property. Taken together, our study highlights the potential role of PRDXs in HNSCC. The function of PRDX5 in the development of HNSCC and the formation of the immune microenvironment makes it a promising potential therapeutic target.

Prdx5 in the Regulation of Tuberous Sclerosis Complex Mutation-Induced Signaling Mechanisms

“…Studies show that cells with a silenced expression of Prdx5 are more vulnerable to oxidative damage and apoptosis [58,68]. According to previous studies, lower Prdx5 levels also correlate with slow tumor growth and reduced infiltration and metastasis capability [69]. In contrast to aggressive and fast-growing tumor types, such as lung adenocarcinoma, a previous study demonstrated variations in Prdx5 mRNA levels as prognostic factors in lung cancer, with low levels of Prdx5 correlating with poor overall survival [70].…”