2021
DOI: 10.2147/ott.s304298
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Comprehensive Analysis of the Relationship Between Metabolic Reprogramming and Immune Function in Prostate Cancer

Abstract: Purpose: Prostate cancer is the most common malignant urinary tumor among men. Treatments are currently unsatisfactory for advanced prostate cancer. Cancer biology remains the basis for developing new antitumor drugs. Therefore, it is crucial to study the metabolic reprogramming, immune microenvironment, and immune evasion of tumors. This study aimed to clarify the relationship between tumor glycolysis and immune function in prostate cancer. Materials and Methods: We downloaded the gene expression matrix and c… Show more

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Cited by 9 publications
(4 citation statements)
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“…In addition, overexpression of centromere protein A (CENPA), a regulator of metabolic reprogramming, may restore growth and glycolysis in tumor cells (46). According to Xie et al (47), the expression of solute carrier family 16 member 3 (SLC16A3), a crucial lactate transporter in glycolysis, was positively correlated with worse DFS and Gleason Score in prostate cancer. Furthermore, it has been reported that phospho-ALDOA facilitates metabolic reprogramming and cell proliferation (48).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, overexpression of centromere protein A (CENPA), a regulator of metabolic reprogramming, may restore growth and glycolysis in tumor cells (46). According to Xie et al (47), the expression of solute carrier family 16 member 3 (SLC16A3), a crucial lactate transporter in glycolysis, was positively correlated with worse DFS and Gleason Score in prostate cancer. Furthermore, it has been reported that phospho-ALDOA facilitates metabolic reprogramming and cell proliferation (48).…”
Section: Discussionmentioning
confidence: 99%
“…Androgen deprivation induces TNF signalling. Further, TNF-mediated prosurvival signalling is a major pathway leading to cell survival and treatment resistance [ 39 ]. Taken together, these data show that multiple pathways can interact to influence PCa cell activity.…”
Section: Discussionmentioning
confidence: 99%
“…The level of glycolytic activity in PCa was associated with significant immune cell infiltration. The IL-17 signaling pathway may have a significant impact on how immune cell infiltration and tumor glycolysis interact [ 131 ]. Moreover, Propionibacterium acnes infection of the prostate organ may have a major impact on the infiltration of CD4 + , IL-17 + , and Treg cells into prostate tissue in patients with benign prostatic hyperplasia (BPH).…”
Section: Proinflammatory Cytokines and CXC Chemokinesmentioning
confidence: 99%