Comprehensive approaches for assessing the safety of probiotic bacteria

Pradhan, Diwas; Mallappa, Rashmi Hogarehalli; Grover, Sunita

doi:10.1016/j.foodcont.2019.106872

Cited by 132 publications

(72 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lactose is especially abundant in human milk [69] and its breakdown can increase dairy intake in populations where lactose intolerance is high. The absence of harmful enzymes such as β-glucuronidase or β-glucosidase, which cause carcinogen formation [70], renders strains safer for human consumption [71]. Being obligately heterofermentative, our strains metabolized various hexose and pentose sugars [50, 72], conducive to their ability to persist in the human intestine and also in non-dairy foods, such as fruits and cereals.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus commensals autochthonous to human milk have the hallmarks of potent probiotics

et al. 2020

View full text Add to dashboard Cite

Maternal milk is an important source of essential nutrients for the optimal growth of infants. Breastfeeding provides a continuous supply of beneficial bacteria to colonize the infant gastrointestinal tract (GIT) and offers health benefits for disease prevention and immunity. The purpose of this study was to isolate novel probiotic strains from the breast milk of native Pakistani mothers and to evaluate their probiotic potential. We isolated 21 strains of bacteria from the colostrum and mature milk of 20 healthy mothers, who had vaginal deliveries and were not taking antibiotics. After phenotypic and genotypic characterization, these isolates were tested for survival in the GIT using in vitro acid and bile tests. Nine strains showing good acid tolerance were assessed for their growth rate, bile resistance and ability to hydrolyze bile salts. Out of the four Lactobacillus isolates adjudged to be most promising as probiotics, three were Lactobacillus fermentum strains and one was a strain of Lactobacillus oris . This study demonstrates that human milk is a viable source of commensal bacteria beneficial to both adults and babies.

show abstract

Section: Discussionmentioning

confidence: 99%

Lactobacillus commensals autochthonous to human milk have the hallmarks of potent probiotics

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Probiotics are live microorganisms that are beneficial to the host by colonizing the human body when administered in adequate amount [99]. Probiotics can change the composition of the microbial communities in a certain organ or tissue of the host [100]. Homeostasis and dysbiosis of oral microbial communities ultimately lead to health or disease, respectively [62].…”

Section: Microbial Cariogenic Biofilm Inhibitors-probioticsmentioning

confidence: 99%

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

et al. 2020

View full text Add to dashboard Cite

Dental caries is one of the most common microbe-mediated oral diseases in human beings. At present, the accepted etiology of caries is based on a four-factor theory that includes oral microorganisms, oral environment, host, and time. Excessive exposure to dietary carbohydrates leads to the accumulation of acid-producing and acid-resistant microorganisms in the mouth. Dental caries is driven by dysbiosis of the dental biofilm adherent to the enamel surface. Effective preventive methods include inhibiting the cariogenic microorganisms, treatment with an anti-biofilm agent, and sugar intake control. The goal is to reduce the total amount of biofilm or the levels of specific pathogens. Natural products could be recommended for preventing dental caries, since they may possess fewer side effects in comparison with synthetic antimicrobials. Herein, the mechanisms of oral microbial community development and functional specialization are discussed. We highlight the application of widely explored natural products in the last five years for their ability to inhibit cariogenic microorganisms.

show abstract

“…Assays should also test probiotic properties in animal models, which will be immunocompromised. Additionally, evaluation of probiotic safety should include tests of anti-mutagenic, anti-carcinogenic, and nonpathogenic probiotic properties [100,101]. Nevertheless, consulting a healthcare expert(s) is always warranted to avoid any issues, regardless of the reasons for probiotic use, especially in cases of serious illness, or hospitalization, which demands close monitoring of patients.…”

Section: Assessment Of Probiotic Safetymentioning

confidence: 99%

“…Altogether, the recent developments of food processing technologies and constant demands from the consumers regarding the more nutritious and safe food products, fruit juices with added probiotics are soon expected to become a new class of functional foods and important element on general food markets, as well as an integral part of proper nutrition [ 143 , 144 ]. This drive is additionally fostered by an increase in vegetarianism where some companies already have probiotic fruit juice beverages in their portfolio for those seeking a healthy lifestyle [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 ...…”

Section: Probiotics: Functional Foodsmentioning

confidence: 99%

Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals

Žuntar

Petrić

Kovačević

2020

Foods

View full text Add to dashboard Cite

Over the last decade, fruit juice consumption has increased. Their rise in popularity can be attributed to the belief that they are a quick way to consuming a dietary portion of fruit. Probiotics added to fruit juices produce various bioactive compounds, thus probiotic fruit juices can be considered as a new type of functional foods. Such combinations could improve nutritional properties and provide health benefits of fruit juices, due to delivering positive health attributes from both sources (fruit juices and probiotics). However, this review discusses the other side of the same coin, i.e., the one that challenges general beliefs that probiotics are undoubtedly safe. This topic deserves more acknowledgments from the medical and nutritional literature, as it is highly important for health care professionals and nutritionists who must be aware of potential probiotic issues. Still, clinical trials have not adequately questioned the safety of probiotics, as they are generally considered safe. Therefore, this reviews aims to give an evidence-based perspective of probiotic safety, focusing on probiotic fruit beverages and nutraceuticals, by providing documented clinical case reports and studies. Finally, the paper deals with some additional insights from the pharmacological and toxicological point of views, such as pharmacological repercussions of probiotics on health.

show abstract

Comprehensive approaches for assessing the safety of probiotic bacteria

Cited by 132 publications

References 141 publications

Lactobacillus commensals autochthonous to human milk have the hallmarks of potent probiotics

Lactobacillus commensals autochthonous to human milk have the hallmarks of potent probiotics

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals

Contact Info

Product

Resources

About