Comprehensive Assessment of Fetal Bilateral Ventriculomegaly Based on Genetic Disorders, Cytomegalovirus Infection, Extra Prenatal Imaging and Pregnancy Outcomes in a Tertiary Referral Center

Guo, Danhua; He, Deqin; Shen, Qingmei; Lin, Ning; He, Shuqiong; Dai, Yifang; Liu, Ying; Xu, Liangpu; Wu, Xiaoqing

doi:10.2147/ijgm.s335011

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…Pregnancies suffering from bacterial, viral, or parasite infections are characterized by abnormal levels of immune blood cells, as extensively discussed in a growing body of research, maternal immunologic biomarkers imbalance can induce negatively affecting on shaping neurodevelopmental trajectories, including regulating neuronal migration and neurogenesis, thus influencing short or long-lasting consequences in fetal postnatal neurodevelopment ( Gumusoglu and Stevens, 2019 ; Cattane et al, 2020 ). Notably, previous studies have been conducted into the link between infection and fetal VM, for example, cytomegalovirus (CMV) infection is an important cause of fetal VM which affects nervous tissue development and leads to neurodevelopmental delay ( Guo et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

et al. 2022

Front. Hum. Neurosci.

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BackgroundFetal ventriculomegaly (VM) is one of the most common abnormalities of the central nervous system (CNS), which can be significantly identified by brain anomalies prenatally by magnetic resonance imaging (MRI). Aberrant white blood cells (WBCs) levels indicate that the maternal is suffering from the infection. Previous studies have confirmed that prenatal infection can affect fetal brain structure, but there is no research revealed the association between maternal blood parameters with fetal VM until now.MethodsWe measured the width of the lateral ventricle of 142 fetuses, which were divided into the fetal VM group (n = 70) and the normal lateral ventricle group (n = 72). We compared maternal blood cell levels between the two groups and investigate potential biomarkers of fetal VM.ResultHigh levels of maternal WBC and neutrophil (NE#) levels were observed in fetuses with VM (p < 0.001), while lymphocyte percentage, monocytes (MO#), neutrophil/lymphocyte ratio (NLR), and platelet were also increased in the fetal VM group (p = 0.033, 0.027, 0.034, and 0.025, respectively). receiver–operator curve (ROC) analysis suggested that WBC and NE# counts might be useful to distinguish fetuses with enlarged lateral ventricles (AUC = 0.688, 0.678, respectively).ConclusionThe current study emphasizes the importance of maternal infection for fetal brain growth, which could provide important information for prenatal diagnosis of CNS anomalies. Future research needs longitudinal analysis and exploration of the influence of maternal blood inflammatory marker levels on fetal brain development.

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Section: Discussionmentioning

confidence: 99%

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

et al. 2022

Front. Hum. Neurosci.

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Hippocampal rotation is associated with ventricular atrial size

Whitehead,

Limperopoulos,

Schlatterer

et al. 2023

Pediatr Radiol

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Clinical characteristics and prediction of neurodevelopmental outcomes of infants with ventriculomegaly in utero: A prospective observational study

Zhou,

Li,

Huo

et al. 2023

Preprint

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Background: To evaluate the clinical features and neurodevelopmental outcomes of infants with fetal ventriculomegaly (VM) and determine prognostic factors. Methods: We studied 167 VM fetuses, assessed the perinatal outcome and the neurodevelopmental outcome at age of 18 months by Bayley Scales of Infant Development. We assessed the association of clinical features and characteristics of VM with Mental Development Index (MDI) and Psychomotor Development Index (PDI). Results: Among the 167 VM fetuses, 23 underwent induced abortion or were stillborn, and 130 completed a thorough VM evaluation and postnatal follow-up. Of 130 cases, 47% (61/130) showed isolated VM and 53% (69/130) non-isolated VM. Non-isolated VM cases had a higher rate of bilateral (52% vs.25%), severe (12% vs.2%), and progressive (16% vs.10%) VM compared with isolated VM. Neurodevelopmental outcome differed between the isolated and non-isolated VM groups, and the mild and severe VM groups. Progressive VM cases had lower PDI (p=0.006). Anomalies in the CNS, urogenital system, and gastrointestinal tract were associated with lower MDI (ORCNS 4.19,95%CI 1.56-11.28;ORUrogenity 7.00,95%CI 1.81-27.07) or PDI (ORCNS 4.61,95%CI 1.79-11.85;ORGastrointestine 7.88,95%CI 1.24-50.18). Cases with lower MDI or PDI were more likely to have multiple anomalies (both CNS and non-CNS anomalies) (MDI: OR 5.78,95%CI 1.57-21.30,p=0.004, PDI: OR 7.20,95%CI 1.98-26.24,p=0.001). Conclusions: The neurodevelopmental outcomes in a fetus with VM were poor when VM was severe or progressive VM, or accompanied by structural anomalies. Cerebral, urogenital, and gastrointestinal structural anomalies contribute to poor neurodevelopmental outcomes.

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Comprehensive Assessment of Fetal Bilateral Ventriculomegaly Based on Genetic Disorders, Cytomegalovirus Infection, Extra Prenatal Imaging and Pregnancy Outcomes in a Tertiary Referral Center

Cited by 5 publications

References 41 publications

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

Maternal blood inflammatory marker levels increased in fetuses with ventriculomegaly

Hippocampal rotation is associated with ventricular atrial size

Clinical characteristics and prediction of neurodevelopmental outcomes of infants with ventriculomegaly in utero: A prospective observational study

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