Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis

Li, Guang; Yang, Meng; Li, Xian; Deng, Shixiong

doi:10.18632/oncotarget.21117

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…Thus, this study confirms that there is no correlation between ERα and PCa expression. However, according to a review study by Bonkhoff et (16). In this study, it was confirmed that ERα is not related to PCa development.…”

Section: Discussionsupporting

confidence: 67%

Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue

Choi

Lee

et al. 2021

Anticancer Res

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Background/Aim: The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). Materials and Methods: From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. Results: ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. Conclusion: AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.Prostate cancer (PCa) is the most prevalent male malignancy in many regions of the world. Remarkable racial and ethnic differences in its incidence have been reported, ranging from 4.4 per 100,000 to 118.2 per 100,000 persons in India and the USA, respectively (1). According to data from the Korea National Statistical Office, in 2012, the prevalence of PCa in Korea over the previous 5 years was reported to be about 37.3 per 100,000 people, and in 2016, increased to about 46.2 per 100,000 individuals (2). Also, according to the The Global Cancer Observatory (GLOBOCAN) results, PCa was the second most frequently diagnosed cancer and the fifth leading cause of cancer mortality among men worldwide in 2012 (1). Therefore, various studies are being conducted to reveal the causes of PCa, and to identify diagnostic and prognostic factors for PCa.Furthermore, there have been few studies on the sirtuin family (SIRT 1-7) to date. Many studies on androgen receptors, which are known to be associated with the onset and progression of PCa, have been published, however, there have not been many studies regarding the role of estrogen receptor α (ERα) and estrogen receptor β (ERβ) in PCa development.Sirtuin is a highly conserved protein family consisting of seven members in mammals (SIRT 1-7) that function in cellular metabolism, chromatin stability, and DNA repair (3). The majority of sirtuins act as NAD+ dependent histone deacetylases, but some of them, can also act as nicotinamide adenine dinucleotide+ (NAD+) dependent Adenosine diphosphate (ADP) ribosyl transferases (4). DNA methylation and histone tail modification are two key epigenetic processes that play vital roles in PCa progression (5).It has been previously reported that SIRT1, a member of the class III histone deacetylases (HDACs), negatively regulates H2A.Z levels in cardiomyocytes through targeting this histone variant to degradation via the ubiquitin/proteasome pathway. In addition, it has been reported that SIRT1 is overexpressed in some cancers, but down-regulated in others. This supports its role as an oncogene or a tumor suppressor gene...

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Section: Discussionsupporting

confidence: 67%

Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue

Choi

Lee

et al. 2021

Anticancer Res

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“…It was reported that substitution of T by C led to loss of PvuII restriction site , and the resulted C allele produced myb transcription factor binding site, significantly increasing transcription compared to the T allele (Herrington et al, 2002). Several diseases, including BC (Zhang et al, 2015;Zhang et al, 2018), endometrial cancer (Ashton et al, 2009), prostate cancer (Li et al,,2017), Alzheimer's disease (Cheng et al, 2014), endometriosis and leiomyoma (Hsieh et al, 2007), and hepatocellular and gallbladder cancer (Sun et al, 2015) were assessed for probable association with PvuII polymorphism. In this study, no genetic association was found between PvuII polymorphism and BC risk.…”

Section: Discussionmentioning

confidence: 99%

Estrogen Receptor 1 Gene (ESR1) rs2234693 Polymorphism and Breast Cancer Risk in Saudi Women

Alamri

Alotibi

AlRaddadi

et al. 2020

Asian Pac J Cancer Prev

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“…ESR1 regulates cell proliferation and differentiation by a hormonal mechanism known as the paracrine mechanism, which is tightly associated with BC development [10]. Genetic variants in human ESR1 have been extensively studied for their role in the susceptibility to various malignancies (e.g., lung, breast, prostate, cervical, ovarian, leiomyoma, gallbladder, and endometrial cancers) in people of multiple ethnicities [11][12][13][14][15]. Two frequently studied polymorphisms (rs2234693 and rs9340799) in the ESR1 gene are found to be associated with the development of BC [16,17].…”

Section: Introductionmentioning

confidence: 99%

Genotype and haplotype analysis between ESR1 variants and breast cancer in the Bangladeshi patients: A PCR-RFLP-based genetic association study

Hossen,

Aziz,

Barek

et al. 2023

Preprint

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Background Breast cancer is the most common cancer among Bangladeshi women, and its pervasiveness is increasing day by day. This case-control study attempted to determine the association between ESR1 polymorphisms and breast cancer susceptibility. Methods This study genotyped two ESR1 genetic variants (rs2234693 and rs9340799) in a total of 399 confirmed breast cancer patients (201 cases and 198 controls) by applying the PCR-RFLP method. SPSS software (v25.0) was used for statistical analysis, and SHEsis web program and Haploview (v4.2) were used for linkage disequilibrium and haplotype analyses, respectively. Results A statistically significant association of rs2234693 variant with grade 3 tumor (OR = 0.17, p = 0.0004) and rs9340799 variant with overweight (OR = 0.46, p = 0.034), infiltrating breast cancer (OR = 0.25, p < 0.0001), and positive lymph node status (OR = 2.34, p = 0.005) were observed. Again, rs2234693 variant was found to be significantly associated with breast cancer in codominant 1 (OR = 0.60, p = 0.045), codominant 2 (OR = 0.50, p = 0.021), dominant (OR = 0.56, p = 0.020), and allelic model (OR = 0.73, p = 0.028). In the case of rs9340799 variant, no significant link was observed for breast cancer. Haplotype analysis revealed a significant correlation of TA and CA haplotypes with breast cancer susceptibility (OR = 1.37, p = 0.028 and OR = 0.41, p = 0.0002, respectively). Besides, both rs2234693 and rs9340799 are found to be in strong linkage disequilibrium (D’=1.00, r2 = 0.697). Conclusions In this study, a significant correlation of ESR1 rs2234693 and rs9340799 genetic variants with breast cancer susceptibility has been observed. The findings of this study need to be investigated further to confirm the association.

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Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis

Cited by 5 publications

References 34 publications

Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue

Expression Patterns of ERα, ERβ, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue

Estrogen Receptor 1 Gene (ESR1) rs2234693 Polymorphism and Breast Cancer Risk in Saudi Women

Genotype and haplotype analysis between ESR1 variants and breast cancer in the Bangladeshi patients: A PCR-RFLP-based genetic association study

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