Comprehensive Assessment of the Elderly Cancer Patient: The Feasibility of Self-Report Methodology

Ingram, Sally S.; Seo, Pearl H.; Martell, Robert E.; Clipp, Elizabeth C.; Doyle, Martha E.; Montana, Gustavo S.; Cohen, Harvey Jay

doi:10.1200/jco.20.3.770

Cited by 107 publications

(56 citation statements)

References 23 publications

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“…31 At least 3 studies have shown that dependence in one or more instrumental activities of daily living (IADL) was as high as 70% and significant comorbidity was present in 40% to 90% of cancer patients aged 70 and older. [32][33][34] The prevalence of memory disorders, malnutrition, and dependence in one or more basic activity of daily living was present in as many as 20% of patients. When compared with an age-matched population without cancer, older cancer patients seemed to be in better health, although, with a reduced number of comorbid conditions and reduced prevalence of functional dependence.…”

Section: Cancer Presentation In the Older Personmentioning

confidence: 99%

Cancer and Age: General Considerations

Hoffe

Balducci

2012

Clinics in Geriatric Medicine

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Section: Cancer Presentation In the Older Personmentioning

confidence: 99%

Cancer and Age: General Considerations

Hoffe

Balducci

2012

Clinics in Geriatric Medicine

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“…The comorbidity burden score was calculated by multiplying each individual's positive condition (defined by a "yes" answer on the survey) by the degree of self-reported interference with daily activities. 7 Degree of interference was categorized as: 1, "not at all"; 2, "somewhat"; and 3, "a great deal." The total range of possible scores was 0 to 42.…”

Section: Methodsmentioning

confidence: 99%

Comorbidity, Chemotherapy Toxicity, and Outcomes Among Older Women Receiving Adjuvant Chemotherapy for Breast Cancer on a Clinical Trial: CALGB 49907 and CALGB 361004 (Alliance)

Klepin

Pitcher

Ballman

et al. 2014

JOP

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Purpose: We evaluated associations among comorbidity, toxicity, time to relapse (TTR), and overall survival (OS) in older women with early-stage breast cancer receiving adjuvant chemotherapy. Cancer and Leukemia Group B 49907 (Alliance) randomly assigned women Ն 65 years old with stages I-III breast cancer to standard adjuvant chemotherapy or capecitabine. We reviewed data from 329 women who participated in the quality of life companion study CALGB 70103 and completed the Physical Health Subscale of the Older American Resources and Services Questionnaire. This questionnaire captures data on 14 comorbid conditions and the degree to which each interferes with daily activities. A comorbidity burden score was computed by multiplying the total number of conditions by each condition's level of interference with function. Outcomes were grade 3 to 5 toxicity, TTR, and OS. Logistic regression was used to evaluate associations between comorbidity and toxicity, and Cox proportional hazards models for TTR and survival. Methods:Results: Number of comorbidities ranged from 0 to 10 (median 2); the comorbidity burden score ranged from 0 to 25 (median 3). The most common conditions were arthritis (58%) and hypertension (55%). Comorbidity was associated with shorter OS, but not with toxicity or TTR. The hazard of death increased by 18% for each comorbidity (hazard ratio [HR] ϭ 1.18, 95% CI ϭ 1.06 to 1.33) after adjusting for age, tumor size, treatment, node and receptor status. Comorbidity burden score was similarly associated with OS (HR ϭ 1.08; 95% CI, 1.03 to 1.14). Conclusions:Among older women enrolled onto a clinical trial, comorbidity was associated with shorter OS, but not toxicity or relapse.

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“…In the assessment of elderly cancer patients, the comprehensive geriatric assessment (CGA) has been useful to demonstrate views of elderly cancer patients concerning with their functional status 1 and quality of life. Besides, elderly cancer patients may be concerned with declining of their quality of life in undertaking cancer treatments (Balducci and Extermann, 2000;Ingram et al, 2002;Repetto et al, 2002).…”

Section: Introductionmentioning

confidence: 99%