Comprehensive bioinformatic analyses of lncRNA-mediated ceRNA network for uterine corpus endometrial carcinoma

Cai, Yiran; Chen, Jin; Wang, Zhisu; Wu, Huiqun

doi:10.21037/tcr-22-249

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…Amongst them, 10 lncRNA, 19 mRNA, and 4 miRs were closely associated with the survival of EC patients (p < 0.05). In 2022, Cai and coworkers analyzed both the TCGA and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases to reconstruct a lncRNA-mediated ceRNA network for uterine corpus endometrial carcinoma [68]. This work allowed identifying tens of these axes, with six of them carrying a high prognostic value.…”

Section: Role Of Circulating Mirna In Ec: Mir Cernet and Cancer Biologymentioning

confidence: 99%

Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects

Piergentili

Gullo

Basile

et al. 2023

IJMS

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This review article explores the possibility of developing an integrated approach to the management of the different needs of endometrial cancer (EC) patients seeking to become pregnant. Life preservation of the woman, health preservation of the baby, a precocious and—as much as possible—minimally invasive characterization of the health and fertility parameters of the patient, together with the concerns regarding the obstetric, neonatal, and adult health risks of the children conceived via assisted reproductive techniques (ART) are all essential aspects of the problem to be taken into consideration, yet the possibility to harmonize such needs through a concerted and integrated approach is still very challenging. This review aims to illustrate the main features of EC and how it affects the normal physiology of pre-menopausal women. We also focus on the prospect of a miR-based, molecular evaluation of patient health status, including both EC early diagnosis and staging and, similarly, the receptivity of the woman, discussing the possible evaluation of both aspects using a single specific panel of circulating miRs in the patient, thus allowing a relatively fast, non-invasive testing with a significantly reduced margin of error. Finally, the ethical and legal/regulatory aspects of such innovative techniques require not only a risk-benefit analysis; respect for patient autonomy and equitable health care access allocation are fundamental issues as well.

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Section: Role Of Circulating Mirna In Ec: Mir Cernet and Cancer Biologymentioning

confidence: 99%

Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects

Piergentili

Gullo

Basile

et al. 2023

IJMS

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“…A comprehensive assessment of transcriptome profile and clinical features has led to identification of a ceRNA network that has prognostic impact in uterine corpus endometrial carcinoma. MEG8 has been among 10 lncRNAs that have been related with prognosis of this type of cancer [ 22 ].…”

Section: Studies In Clinical Samplesmentioning

confidence: 99%

A review on the role of MEG8 lncRNA in human disorders

et al. 2022

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Maternally expressed 8 (MEG8) is a long non-coding RNA which is expressed in the nucleus. It is highly expressed in adrenal, placenta and brain. Recent studies have shown contribution of MEG8 in different disorders ranging from neoplastic ones to diabetic nephropathy, atherosclerosis, ischemic stroke, trophoblast dysfunction and abortion, Henoch-Schonlein purpura and osteoarthritis. It has an oncogenic role in the development of lung, pancreatic and liver cancer. In the current review, we summarize the role of this lncRNA in mentioned disorders, based on the evidence obtained from in vitro, in vivo and human studies.

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“…WGCNA has been proven to be an exceedingly effective approach for identifying potential biomarkers or therapeutic targets (17)(18)(19)(20)(21)(22). Different from the protein-protein interaction (PPI) network which reflect relationships between proteins, or the competing endogenous RNA (ceRNA) regulatory network which evaluate the associations between RNAs, WGCNA begins with the generation of scale-free gene coexpression networks that describe the pairwise expression similarities among genes (23)(24)(25). Then, modules are detected using unsupervised clustering with hierarchical clustering as a default method choice.…”

Section: Introductionmentioning

confidence: 99%

Identification of novel key genes associated with uterine corpus endometrial carcinoma progression and prognosis

Li¹,

Zhou²,

Wu³

et al. 2023

Ann Transl Med

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Background Uterine corpus endometrial carcinoma (UCEC) is a common malignant cancer type which affects the health of women worldwide. However, its molecular mechanism has not been elucidated. Methods To identify the hub modules and genes in UCEC associated with clinical phenotypes, the RNA sequencing data and clinical data of 543 UCEC samples were obtained from The Cancer Genome Atlas (TCGA) database and then subjected to weighted gene co-expression network analysis (WGCNA). To explore the potential biological function of the hub modules, Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted. Genes differentially expressed in UCEC were screened according to TCGA data using the “gdcDEAnalysis” package in R (The R Foundation for Statistical Computing). After intersecting with hub genes, the shared genes were used for further survival analyses. The relationship between gene expression level and clinical phenotype was analyzed in the TCGA-UCEC cohort in The University of ALabama at Birmingham CANcer data analysis Portal and the Human Protein Atlas. The microarray data set GSE17025 was also analyzed to validate the gene expression profiles. Results There were 19 coexpression modules generated by WGCNA. Among them, 2 modules with 198 hub genes were highly correlated with clinical features (especially histologic grade and clinical stage). Meanwhile, 4,003 differentially expressed genes (DEGs) were screened out, and 164 DEGs overlapped with hub genes. Survival analyses revealed that high expression of GINS4 and low expression of ESR1 showed a trend of poor prognosis. Further analyses demonstrated that both messenger RNA (mRNA) and protein expression profiles of GINS4 and ESR1 were significantly associated with UCEC development and progression in TCGA and GSE17025 cohorts. Conclusions Based on the integrated bioinformatic analyses, our data indicated that GINS4 and ESR1 might serve as potential prognostic markers and targets for UCEC therapy.

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Comprehensive bioinformatic analyses of lncRNA-mediated ceRNA network for uterine corpus endometrial carcinoma

Cited by 6 publications

References 47 publications

Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects

Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects

A review on the role of MEG8 lncRNA in human disorders

Identification of novel key genes associated with uterine corpus endometrial carcinoma progression and prognosis

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