Comprehensive Characterization of Cancer Driver Genes and Mutations

Solid pseudopapillary neoplasms of the pancreas are dependent on the Wnt pathway

“…CTNNB1 mutation frequencies were assessed in 10 100 common cancers from The Cancer Genome Atlas (TCGA) (Bailey et al ., ; Gao et al ., ), including 175 pancreatic ADCs. In addition, mutational data from 8 SPNs from Wu et al .…”

Intratumour heterogeneity of p53 expression; causes and consequences

“…Data from The Cancer Genome Atlas (TCGA) as part of the Pan‐Cancer Initiative have confirmed the role of TP53 as the most prominent cancer driver gene . The most recent study covering over 9000 tumour exomes across over 30 different cancer types found TP53 mutations to be associated with 27 cancer types . Mutant p53 proteins can accumulate in cancer cells harbouring the mutant genes.…”

Cancer‐associated missense mutations enhance the pluripotency reprogramming activity of OCT4 and SOX17

“…Yet, within the SOX family, SOX17 has the highest mutation rate followed by SOX9 and SOX2. Accordingly, SOX17 and SOX9 have been classified as mutational cancer drivers by The Cancer Genome Atlas in endometrial cancer and colorectal adenocarcinoma, respectively . Therefore, dissecting the functional impact of missense mutations is of particular interest to these SOX factors.…”

“…SOX17 has been classified as ‘likely oncogene’ in endometrial cancer for the presence of recurring missense mutations . Yet, dedicated analysis predicts that WT SOX17 acts as a tumor suppressor by antagonizing the canonical Wnt/β‐catenin pathway .…”

“…SOX17 normally does not support pluripotency induction when substituted for SOX2 . We nevertheless included SOX17 in our study for its demonstrated conversion into a pluripotency inducer with single missense mutation and its classification as mutated cancer driver gene in endometrial cancer .…”