2022
DOI: 10.1002/bkcs.12602
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Comprehensive identification of VX‐adducted plasma proteins using high‐resolution mass spectrometry

Abstract: VX is one of the chemical warfare agents that attack victims' nervous systems and ultimately lead to their death. Upon VX exposure, circulating proteins in the bloodstream can be modified with VX that may produce diagnostic VX adducts. Thus, these adducts would be key evidence for the forensic investigation against chemical warfare or terrorism. In this study, we discovered a list of potential blood protein biomarkers for VX exposure. To do so, we employed highresolution mass spectrometry-based proteomics and … Show more

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“…Data dependent acquisition (DDA) is the most common scan mode in LC-MS/MS analysis [ 27 , 28 , 29 , 30 , 31 ]. DDA methods have been initially used for single cell proteomics analysis [ 23 , 25 , 32 ].…”
Section: Label-free Single-cell Proteomic Analysismentioning
confidence: 99%
“…Data dependent acquisition (DDA) is the most common scan mode in LC-MS/MS analysis [ 27 , 28 , 29 , 30 , 31 ]. DDA methods have been initially used for single cell proteomics analysis [ 23 , 25 , 32 ].…”
Section: Label-free Single-cell Proteomic Analysismentioning
confidence: 99%