Comprehensive insight into functional interaction between GNB3 C825T and eNOS T‐786C, G894T gene polymorphisms and association with susceptibility to diabetic erectile dysfunction

Khedher, Mohamed Raâfet Ben; Abid, M.; Jamoussi, Kamel; Hammami, Mohamed

doi:10.1111/andr.12543

Cited by 8 publications

(2 citation statements)

References 35 publications

(55 reference statements)

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“…In addition to diabetes, there have been numerous human and animal studies that have shown the abnormal effects of lipid-related tests on ED, especially when associated with diabetes. Generally, dyslipidemia is a risk factor for ED patients who also suffer from diabetes (15).…”

Section: Introductionmentioning

confidence: 99%

Investigation of gene expression and genetic simultaneous control associated with erectile dysfunction and diabetes

Kazemi

Zargooshi

Kaboudi

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Diabetes can cause some diseases or abnormalities. One of the disorders caused by diabetes may be erectile dysfunction (ED). ED is sexual dysfunction characterized by the inability to establish or maintain an erect penis during sexual activity and is a complication of men with chronic type 2 diabetes. These processes, disorders and diseases are highly influenced by the genetics of individuals. In this study, the relationship between genes and diabetes and ED has been explored by a system biology approach. For this purpose, the samples from ten control and diabetic-ED rats were collected. After a search in Gene Expression Omnibus (GEO), series with accession number GSE2457 comprising of 5 normal and 5 diabetic-ED rats were selected. Raw CEL files of these samples were normalized with robust multi-array average (RMA) expression measure method by using the linear models for microarray data (LIMMA) R package. The extracted probe IDs were transformed into 10451 unique and validated official gene symbols. Then, differentially expressed genes (DEGs) were identified between control and normal mucosa by employing the LIMMA R package. DEGs were classified by utilizing KEGG to underlying pathways by Enrichr. The expression values of DEGs were used to construct a gene regulatory network (GRN), by the GENEI3 R package. To analyze the topology of constructed GRNs, betweenness centrality was calculated. Genes with higher betweenness centrality scores were then identified, through the CytoNCA. We then took the commonality of DEGs genes and high-top ranking genes from CytoNCA via a predicted interaction network using GeneMANIA as the most likely important genes in erectile dysfunction. Among the 374 DEGs studied, 146 DEGs showed up-regulation and 228 DEGs displayed down-regulation expression in diabetic-ED rats. According to the Volcano plot, the dpp4, LOC102553868, Ndufa412, Oxct1, Atp2b3 and Zfp91 gene down-regulated and Lpl, Retsat, B4galt1 and Pdk4 genes up-regulated in ED and diabetic rats. Furthermore, genes like dpp4 acted as hubs in the inferred GRN.

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Section: Introductionmentioning

confidence: 99%

Investigation of gene expression and genetic simultaneous control associated with erectile dysfunction and diabetes

Kazemi

Zargooshi

Kaboudi

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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“…One of the eNOS gene variants is G894T [49] . The singlenucleotide polymorphism at position 298 in exon 7 led to the transversion of guanine with thymine, resulting in the substitution of glutamate with aspartate in the mature protein [49][50][51][52] . This polymorphism increases the selective proteolytic cleavage of endothelial cells and vascular tissue leading to the reduction in the NOS activity and subsequent decrease in the production of vascular NO.…”

Section: Genetic Factors Associated With Sexual Dysfunction In T2dmmentioning

confidence: 99%

Sexual Dysfunction in Asian Males with Type 2 Diabetes Mellitus

Venggadasamy

Ho²,

Ahmad³

et al. 2021

Prog Micobes Mol Biol

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In 2021, 537 million people were diagnosed with diabetes globally, where over 90% of these cases were type 2 diabetes mellitus (T2DM). In the top 10 countries for many adults with diabetes in 2021, Asia accounted for six spots in the rankings, with China (140.9 million), India (74.2 million), and Pakistan (33 million) sitting at the top three. In addition, the prevalence of diabetes in Asians are higher than in individuals from other regions. In Asia, diabetes affects a younger age group resulting in more people suffering from the complications of diabetes at an earlier stage in life. One of the most serious diabetes mellitus (DM) complications is sexual dysfunction (SD). In men with diabetes, several issues may occur in SD, such as erectile dysfunction (ED), ejaculatory disorders, orgasmic disorders, and reduced libido. There are many tools available to assess SDs. However, the Sexual Dysfunction in Asian Men with Diabetes (SAD-MEN) questionnaire is the only tool specific to Asian males with diabetes. SD develops because of the interaction between several biopsychosocial factors. There is insufficient data on the genetic, psychological, and social factors contributing to SDs in males with diabetes in Asia. Men with diabetes induced SDs experience a poor quality of life (QoL) due to the distress caused by SD. However, people from different cultural backgrounds and ethnicities perceive QoL differently. Therefore, future studies must be done on other predictors of life in a multiethnic population like Southeast Asians. There is still insufficient data on SDs in Asian males with diabetes. More studies are warranted to research different aspects of SDs, such as its prevalence in other parts of Asia, biopsychosocial factors contributing to SD, and the impact of SD on the quality of life of males with diabetes.

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The Complex Relationship Between Erectile Dysfunction and Hypogonadism in Diabetes Mellitus

Holland

Beilan

Tatem

et al. 2019

Curr Sex Health Rep

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Comprehensive insight into functional interaction between GNB3 C825T and eNOS T‐786C, G894T gene polymorphisms and association with susceptibility to diabetic erectile dysfunction

Abstract: Our study gave a comprehensive insight into functional interaction between GNB3 and eNOS gene polymorphisms and suggests that the eNOS G894T and T-786C variants are strong predisposing factors of VED susceptibility within men with type 2 diabetes.

Cited by 8 publications

References 35 publications

Investigation of gene expression and genetic simultaneous control associated with erectile dysfunction and diabetes

Investigation of gene expression and genetic simultaneous control associated with erectile dysfunction and diabetes

Sexual Dysfunction in Asian Males with Type 2 Diabetes Mellitus

The Complex Relationship Between Erectile Dysfunction and Hypogonadism in Diabetes Mellitus

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