Comprehensive morphomechanical analysis of brain aneurysms

Raghuram, Ashrita; Galloy, Adam; Nino, Marco A.; Sanchez, Sebastian; Hasan, David; Raghavan, Suresh M. L.; Samaniego, Edgar A

doi:10.1007/s00701-022-05476-4

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…This is partly attributed to the expansion of gap junctions between endothelial cells, which may facilitate the uptake and deposition of lipids, promoting plaque formation. [80][81][82] CFD analysis may shed light on the morphological transformations within atherosclerotic plaques post-formation. Symptomatic plaques are often characterized by a large lipid core beneath a delicate fibrous cap.…”

Section: Hemodynamic Analysis Of Intracranial Atherosclerotic Plaquesmentioning

confidence: 99%

Comprehensive imaging analysis of intracranial atherosclerosis

Sanchez,

Mossa-Basha,

Anagnostakou

et al. 2024

J NeuroIntervent Surg

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Intracranial atherosclerotic disease (ICAD) involves the build-up of atherosclerotic plaques in cerebral arteries, significantly contributing to stroke worldwide. Diagnosing ICAD entails various techniques that measure arterial stenosis severity. Digital subtraction angiography, CT angiography, and magnetic resonance angiography are established methods for assessing stenosis. High-resolution MRI offers additional insights into plaque morphology including plaque burden, hemorrhage, remodeling, and contrast enhancement. These metrics and plaque traits help identify symptomatic plaques. Techniques like transcranial Doppler, CT perfusion, computational fluid dynamics, and quantitative MRA analyze blood flow restrictions due to ICAD. Intravascular ultrasound or optical coherence tomography have a very high spatial resolution and can assess the structure of the arterial wall and the plaque from the lumen of the target vascular territory. Positron emission tomography could further detect inflammation markers. This review aims to provide a comprehensive overview of the spectrum of current modalities for atherosclerotic plaque analysis and risk stratification.

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Section: Hemodynamic Analysis Of Intracranial Atherosclerotic Plaquesmentioning

confidence: 99%