Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions

Rarani, Fahimeh Zamani; Rarani, Mohammad Zamani; Hamblin, Michael R.; Rashidi, Bahman; Hashemian, Seyed Mohammad Reza; Mirzaei, Hamed

doi:10.1186/s11658-022-00363-3

Cited by 8 publications

(3 citation statements)

References 217 publications

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“…Except for cytokines, L. pentosus CCFM1227 also affected the levels of blood immunocytes ( Figure S1c–f ), particularly platelets ( Figure S1f ). Platelets contain TLRs and TNF receptors, which are essential for activating immune responses [ 30 ]. The cross-cation of platelets and neutrophils tightly regulates host immune and complement responses as the initial intrinsic defense against influenza [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Lactiplantibacillus pentoses CCFM1227 Produces Desaminotyrosine to Protect against Influenza Virus H1N1 Infection through the Type I Interferon in Mice

Wang,

Fang,

Xiao

et al. 2023

Nutrients

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Microbiota-derived desaminotyrosine (DAT) protects the host from influenza by modulating the type I interferon (IFN) response. The aim of this study was to investigate the antivirus effects of a DAT-producing bacteria strain. A comparative genomics analysis and UHPLC Q-Exactive MS were used to search for potential strains and confirm their ability to produce DAT, respectively. The anti-influenza functions of the DAT producer were evaluated using an antibiotic-treated mouse model by orally administering the specific strain before viral infection. The results showed the Lactiplantibacillus pentosus CCFM1227 contained the phy gene and produced DAT by degrading phloretin. In vivo, L. pentosus CCFM1227 re-inoculation increased the DAT level in feces, and protected from influenza through inhibiting viral replication and alleviating lung immunopathology. Furthermore, CCFM1227-derived DAT was positively correlated with the IFN-β level in the lung. The transcriptome results showed that CCFM1227 activated gene expression in the context of the defense response to the virus, and the response to interferon-beta. Moreover, CCFM1227 treatment upregulated the expression of MHC-I family genes, which regulate the adaptive immune response. In conclusion, L. pentosus CCFM1227 exerted antiviral effects by producing DAT in the gut, and this may provide a potential solution for creating effective antiviral probiotics.

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Section: Discussionmentioning

confidence: 99%

Lactiplantibacillus pentoses CCFM1227 Produces Desaminotyrosine to Protect against Influenza Virus H1N1 Infection through the Type I Interferon in Mice

Wang,

Fang,

Xiao

et al. 2023

Nutrients

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“…Appropriate neutrophil apoptosis is important for the resolution of inflammation (Driss and Filep, 2010). Platelets have a variety of transmembrane receptors, including TLRs and TNF receptors, which might be associated with the regulation of immune responses (Zamani-Rarani et al, 2022). During COVID-19, platelets play an important role in the host's antiviral responses (Trugilho et al, 2022).…”

Section: Probiotics Might Regulate the Expression Of Pro-andmentioning

confidence: 99%

Lactobacillus mucosae exerted different antiviral effects on respiratory syncytial virus infection in mice

Wang

Fang

et al. 2022

Front. Microbiol.

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Respiratory syncytial virus (RSV) infection is a constant threat to the health of young children, and this is mainly attributed to the lack of effective prevention strategies. This study aimed to determine whether Lactobacillus (L.) mucosae, a potential probiotic, could protect against respiratory viral infection in a mouse model. Naive 3–4-week-old BALB/c mice were orally administered with three L. mucosae strains (2.5 × 108 CFU/mouse) 7 days before RSV infection (105 TCID50/mouse). Results showed that all three strains inhibited RSV replication and reduced the proportions of inflammatory cells, including granulocytes and monocytes in the blood. The L. mucosae M104R01L3 treatment maintained stable weight in mice and increased interferon (IFN)-β and tumor necrosis factor (TNF)-α levels. The L. mucosae DCC1HL5 treatment increased interleukin (IL)-1β and IL-10 levels. Moreover, the M104R01L3 and DCC1HL5 strains increased the proportions of Akkermansia, Alistipes, and Anaeroplasma which contributed to the advantageous modulation of the gut microbiota. Besides, L. mucosae affected the gut levels of short-chain fatty acids (SCFAs) that are important for the antiviral response. L. mucosae 1,025 increased acetate, propionate, and butyrate levels, whereas L. mucosae M104R01L3 increased the level of acetate in the gut. L. mucosae M104R01L3 may protect against viral infection by upregulating the IFN-β levels in the lungs and its antiviral effect may be related to the increase of acetate levels in the gut. In conclusion, the three L. mucosae strains exerted antiviral effects against RSV infection by differentially regulating immune responses and intestinal micro-ecological balance. This study can provide a reference for studying the mechanisms underlying the antiviral effects of L. mucosae.

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“…SARS-CoV-2 is generally spread when aerosolized droplets from an infected person come into contact with a healthy person’s mucous membranes (i.e., the eyes, nose, or mouth) or through direct physical contact between an infected and uninfected person [ 4 ]. Some infected patients may present as asymptomatic [ 5 ], while other cases involve fever, cough, and unexplained fatigue [ 6 , 7 ]; more severe cases can result in hospitalization for respiratory failure [ 7 ], heart failure [ 8 ], or sepsis [ 9 ]. Since SARS-CoV-2 is capable of rapid transmission, and has proven to result in drastic health consequences, there is a pressing need for effective surveillance testing.…”

Section: Introductionmentioning

confidence: 99%

The Use of Biological Sensors and Instrumental Analysis to Discriminate COVID-19 Odor Signatures

et al. 2022

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The spread of SARS-CoV-2, which causes the disease COVID-19, is difficult to control as some positive individuals, capable of transmitting the disease, can be asymptomatic. Thus, it remains critical to generate noninvasive, inexpensive COVID-19 screening systems. Two such methods include detection canines and analytical instrumentation, both of which detect volatile organic compounds associated with SARS-CoV-2. In this study, the performance of trained detection dogs is compared to a noninvasive headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) approach to identifying COVID-19 positive individuals. Five dogs were trained to detect the odor signature associated with COVID-19. They varied in performance, with the two highest-performing dogs averaging 88% sensitivity and 95% specificity over five double-blind tests. The three lowest-performing dogs averaged 46% sensitivity and 87% specificity. The optimized linear discriminant analysis (LDA) model, developed using HS-SPME-GC-MS, displayed a 100% true positive rate and a 100% true negative rate using leave-one-out cross-validation. However, the non-optimized LDA model displayed difficulty in categorizing animal hair-contaminated samples, while animal hair did not impact the dogs’ performance. In conclusion, the HS-SPME-GC-MS approach for noninvasive COVID-19 detection more accurately discriminated between COVID-19 positive and COVID-19 negative samples; however, dogs performed better than the computational model when non-ideal samples were presented.

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Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions

Cited by 8 publications

References 217 publications

Lactiplantibacillus pentoses CCFM1227 Produces Desaminotyrosine to Protect against Influenza Virus H1N1 Infection through the Type I Interferon in Mice

Lactiplantibacillus pentoses CCFM1227 Produces Desaminotyrosine to Protect against Influenza Virus H1N1 Infection through the Type I Interferon in Mice

Lactobacillus mucosae exerted different antiviral effects on respiratory syncytial virus infection in mice

The Use of Biological Sensors and Instrumental Analysis to Discriminate COVID-19 Odor Signatures

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