Comprehensive overview of the analytical methods for determining pyrrolizidine alkaloids and their derived oxides in foods

Fuente-Ballesteros, Adrián; Brabenec, Ondrej; Tsagkaris, Aristeidis S.; Ares, Ana M.; Hajslova, Jana; Bernal, José

doi:10.1016/j.jfca.2023.105758

Cited by 5 publications

(1 citation statement)

References 160 publications

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“…9,17 • ing with mACh and 5-HT 2 receptors. 10,27,28 • Quinolizidine alkaloids Quinolizidine alkaloids are heterocyclic compounds with a common nitrogen atom between two six-membered rings. This class of alkaloids is mainly isolated from members of the plant genus Lupinus.…”

Section: • Indole Alkaloidsmentioning

confidence: 99%

An insight into recent updates on analytical techniques for bioactive alkaloids

Saini,

Seni,

Chawla

et al. 2024

Phytochemical Analysis

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IntroductionAlkaloids represent a wide class of naturally existing nitrogen‐containing organic compounds having diverse biological activities. They are primary bioactive substances extracted from diverse plant parts. Due to their diverse biological activities, they are frequently used as medicines. The alkaloids have diverse pharmacological impacts on the human body; alkaloids are used for prevention, treatment, and reduction of discomfort associated with chronic illnesses. As most alkaloids exist in plants in complex form, combined with numerous other natural plant components, it is essential to recognize and characterize these molecules using different analytical techniques.ObjectivesWe aimed to review the literature on the methods and protocols for the analysis of naturally occurring alkaloids.MethodsWe carried out a literature survey using the PubMed, Scopus, and Google Scholar databases and other relevant published materials. The keywords used in the searches were “alkaloids,” “analytical methods,” “HPLC method,” “GC method,” “electrochemical methods,” and “bioanalytical methods,” in various combinations.ResultsIn this article, several classes of alkaloids are presented, along with their biological activities. Moreover, it includes a thorough explanation of chromatographic techniques, hyphenated techniques, electrochemical techniques, and current trending analytical methods utilized for the isolation, identification, and comprehensive characterization of alkaloids.ConclusionsThe various analytical techniques play an important role in the identification as well as the characterization of various alkaloids from plants, plasma samples, and urine samples. The hyphenation of various chromatographic techniques with mass spectrometry and NMR spectroscopy plays a crucial role in the characterization of unknown compounds.

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Section: • Indole Alkaloidsmentioning

confidence: 99%

An insight into recent updates on analytical techniques for bioactive alkaloids

Saini,

Seni,

Chawla

et al. 2024

Phytochemical Analysis

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The single adsorbent nano-TiO2 modified QuEChERS for simultaneous determination of 18 pyrrolizidine alkaloids in ginseng samples via LC-MS/MS

Jiao,

Liu,

Jin

et al. 2024

Microchemical Journal

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Underexplored food safety hazards of beekeeping products: Key knowledge gaps and suggestions for future research

Végh,

Csóka,

Sörös

et al. 2024

Comp Rev Food Sci Food Safe

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These days, a growing consumer demand and scientific interest can be observed for nutraceuticals of natural origin, including apiculture products. Due to the growing emphasis on environmental protection, extensive research has been conducted on the pesticide and heavy metal contamination of bee products; however, less attention is devoted on other food safety aspects. In our review, scientific information on the less‐researched food safety hazards of honey, bee bread, royal jelly, propolis, and beeswax are summarized. Bee products originating from certain plants may inherently contain phytotoxins, like pyrrolizidine alkaloids, tropane alkaloids, matrine alkaloids, grayanotoxins, gelsemium alkaloids, or tutin. Several case studies evidence that bee products can induce allergic responses to sensitive individuals, varying from mild to severe symptoms, including the potentially lethal anaphylaxis. Exposure to high temperature or long storage may lead to the formation of the potentially toxic 5‐hydroxymethylfurfural. Persistent organic pollutants, radionuclides, and microplastics can potentially be transferred to bee products from contaminated environmental sources. And lastly, inappropriate beekeeping practices can lead to the contamination of beekeeping products with harmful microorganisms and mycotoxins. Our review demonstrates the necessity of applying good beekeeping practices in order to protect honeybees and consumers of their products. An important aim of our work is to identify key knowledge gaps regarding the food safety of apiculture products.

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Comprehensive overview of the analytical methods for determining pyrrolizidine alkaloids and their derived oxides in foods

Cited by 5 publications

References 160 publications

An insight into recent updates on analytical techniques for bioactive alkaloids

An insight into recent updates on analytical techniques for bioactive alkaloids

The single adsorbent nano-TiO2 modified QuEChERS for simultaneous determination of 18 pyrrolizidine alkaloids in ginseng samples via LC-MS/MS

Underexplored food safety hazards of beekeeping products: Key knowledge gaps and suggestions for future research

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