Comprehensive pan-carcinoma analysis of ITGB1 distortion and its potential clinical significance for cancer immunity

Abstract

The human protein-coding gene ITGB1 (Integrin 1), also known as CD29, has a length of 58048 base pairs. The Integrin family's most prevalent subunit, it participates in the transmission of numerous intracellular signaling pathways. A thorough examination of ITGB1's functions in human malignancies, however, is inadequate and many of their relationships to the onset and development of human cancers remain unknown. In this work, we examined ITGB1's role in 33 human cancers. Finally, a multi-platform analysis revealed that three of the 33 malignancies had significantly altered ITGB1 expression in tumor tissues in comparison to normal tissues. In addition, it was discovered through survival analysis that ITGB1 was a stand-alone prognostic factor in a number of cancers. ITGB1 expression was linked to immune cell infiltration in colon cancer, according to an investigation of immune infiltration in pan-cancer. In the gene co-expression research, ITGB1 showed a positive connection with the majority of the cell proliferation and EMT indicators, indicating that ITGB1 may have an essential function in controlling cancer metastasis and proliferation. Our pan-cancer analysis of ITGB1 gives evidence in favor of a further investigation into its oncogenic function in various cancer types.

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“…Fei et al found that ITGB1 was positively correlated with most indicators of cell proliferation in a gene co-expression study. This suggests that ITGB1 has an important role in controlling cancer metastasis and proliferation 40 . Matrix metalloproteinase-9 (MMP-9) is a Matrix metalloproteinase that helps degrade parts of the extracellular matrix and has also been found to be involved in processes such as inflammation, cancer invasion and metastasis 41 .…”