Comprehensive phenotyping of salt-induced hypertensive heart disease in living mice using cardiac magnetic resonance

Cochet, Hubert; Lefrançois, William; Montaudon, Michel; Laurent, François; Pourtau, Line; Miraux, Sylvain; Parzy, Elodie; Franconi, Jean‐Michel; Thiaudière, Eric

doi:10.1007/s00330-012-2598-8

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Although estimating salt consumption at the population level is challenging, this diet is comparable to the high end of the spectrum of human salt consumption 19 . Consistent with previous reports 20 , HSD induced a nonsignificant trend toward a reduction in body weight and increased caloric intake (Supplementary Fig. 1a), but did not increase arterial pressure (Fig.…”

Section: Resultssupporting

confidence: 92%

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

et al. 2018

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A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. We report that, in mice, excess dietary salt suppresses resting cerebral blood flow and endothelial function, leading to cognitive impairment. The effect depends on expansion of TH17 cells in the small intestine, resulting in a marked increase in plasma interleukin-17 (IL-17). Circulating IL-17, in turn, promotes endothelial dysfunction and cognitive impairment by the Rho kinase-dependent inhibitory phosphorylation of endothelial nitric oxide synthase and reduced nitric oxide production in cerebral endothelial cells. The findings reveal a new gut-brain axis linking dietary habits to cognitive impairment through a gut-initiated adaptive immune response compromising brain function via circulating IL-17. Thus, the TH17 cell-IL-17 pathway is a putative target to counter the deleterious brain effects induced by dietary salt and other diseases associated with TH17 polarization.

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Section: Resultssupporting

confidence: 92%

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

et al. 2018

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“…These findings were consistent for diseased mice as well as for healthy controls. LVEF in our study (52.02%±7.72) was reduced by ∼20% compared to MRI data of healthy control mice (mean 62.4±3.1%) [11] , [16] , [17] , [21] .…”

Section: Resultscontrasting

confidence: 60%

The Role of 1.5 Tesla MRI and Anesthetic Regimen Concerning Cardiac Analysis in Mice with Cardiomyopathy

et al. 2014

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Accurate assessment of left ventricular function in rodent models is essential for the evaluation of new therapeutic approaches for cardiac diseases. In our study, we provide new insights regarding the role of a 1.5 Tesla (T) magnetic resonance imaging (MRI) device and different anesthetic regimens on data validity. As dedicated small animal MRI and echocardiographic devices are not broadly available, we evaluated whether monitoring cardiac function in small rodents with a clinical 1.5 T MRI device is feasible. On a clinical electrocardiogram (ECG) synchronized 1.5 T MRI scanner we therefore studied cardiac function parameters of mice with chronic virus-induced cardiomyopathy. Thus, reduced left ventricular ejection fraction (LVEF) could be verified compared to healthy controls. However, our results showed a high variability. First, anesthesia with medetomidine, midazolam and fentanyl (MMF) led to depressed cardiac function parameters and more variability than isoflurane gas inhalation anesthesia, especially at high concentrations. Furthermore, calculation of an average ejection fraction value from sequenced scans significantly reduced the variance of the results. To sum up, we introduce the clinical 1.5 T MRI device as a new tool for effective analysis of left ventricular function in mice with cardiomyopathy. Besides, we suggest isoflurane gas inhalation anesthesia at high concentrations for variance reduction and recommend calculation of an average ejection fraction value from multiple sequenced MRI scans to provide valid data and a solid basis for further clinical testing.

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“…Baudrand et al 7 reported that a high salt diet was associated with dyslipidaemia and hypoadiponectinaemia, and predicted metabolic syndrome (MS) status. Studies have shown that administration of a high salt diet to normal rats induced hypertension and MS. [11][12][13] Elevated salt intake can also increase le ventricular mass in humans 14 and animals, 15 and further increase the risk of cardiovascular disease. Consequently, it is vital to examine the effects of excessive dietary salt intake on the metabonome systematically and the time-dependent metabolic trajectories induced by this dietary pattern, in order to explore the pathogenesis of HT from the perspective of metabolic regulation.…”

Section: Introductionmentioning

confidence: 99%

A¹H NMR-based metabonomic investigation of time-dependent metabolic trajectories in a high salt-induced hypertension rat model

et al. 2015

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Comprehensive phenotyping of salt-induced hypertensive heart disease in living mice using cardiac magnetic resonance

Abstract: Phenotyping of hypertensive heart disease is feasible in living mice using dynamic MR angiography and time-resolved 3D black-blood manganese-enhanced MRI. HSD is associated with early impairment of coronary reserve, before the onset of significant hypertrophy.

Cited by 5 publications

References 19 publications

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

The Role of 1.5 Tesla MRI and Anesthetic Regimen Concerning Cardiac Analysis in Mice with Cardiomyopathy

A¹H NMR-based metabonomic investigation of time-dependent metabolic trajectories in a high salt-induced hypertension rat model

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Comprehensive phenotyping of salt-induced hypertensive heart disease in living mice using cardiac magnetic resonance

Abstract: Phenotyping of hypertensive heart disease is feasible in living mice using dynamic MR angiography and time-resolved 3D black-blood manganese-enhanced MRI. HSD is associated with early impairment of coronary reserve, before the onset of significant hypertrophy.

Cited by 5 publications

References 19 publications

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

The Role of 1.5 Tesla MRI and Anesthetic Regimen Concerning Cardiac Analysis in Mice with Cardiomyopathy

A1H NMR-based metabonomic investigation of time-dependent metabolic trajectories in a high salt-induced hypertension rat model

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A¹H NMR-based metabonomic investigation of time-dependent metabolic trajectories in a high salt-induced hypertension rat model