Comprehensive plaque assessment with serial coronary CT angiography: translation to bedside

Lakshmanan, Suvasini; Rezvanizadeh, Vahid; Budoff, Matthew J.

doi:10.1007/s10554-020-01849-x

Cited by 12 publications

(6 citation statements)

References 78 publications

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“…The quantitative evaluation of TOCAB can help identify subjects at high risk, and can also be of value for directly assessing the efficiency of preventive actions, pharmacological as well as non-pharmacological, on the atherosclerotic plaques themselves. 20,21 This important technological step can lead to a significant improvement in the prevention of cardiovascular accidents.…”

Section: Total Coronary Atheroma Burden Is a Powerful Risk Predictormentioning

confidence: 99%

The Quantification of Total Coronary Atheroma Burden – A Major Step Forward

Foult¹,

Pranesh²,

Budoff³

2020

Heart International

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Section: Total Coronary Atheroma Burden Is a Powerful Risk Predictormentioning

confidence: 99%

The Quantification of Total Coronary Atheroma Burden – A Major Step Forward

Foult¹,

Pranesh²,

Budoff³

2020

Heart International

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“…CCTA detects severe CAV (> 50% lumen narrowing) with a sensitivity of 94%, specificity of 92%, negative predictive value of 99%, positive predictive value of 67%, and diagnostic accuracy of 94% [10]. In addition, CCTA provides more detailed anatomic information including coronary plaque characteristics, is safer, and is more costeffective than ICA [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of perivascular fat attenuation with coronary CT angiography in cardiac transplantation patients: an imaging biomarker candidate for prediction of cardiac mortality and re-transplantation

et al. 2023

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Objectives In cardiac transplant recipients, non-invasive allograft surveillance for identifying patients at risk for graft failure remains challenging. The fat attenuation index (FAI) of the perivascular adipose tissue in coronary computed tomography angiography (CCTA) predicts outcomes in coronary artery disease in non-transplanted hearts; however, it has not been evaluated in cardiac transplant patients. Methods We followed 39 cardiac transplant patients with two or more CCTAs obtained between 2010 and 2021. We performed FAI measurements around the proximal 4 cm segments of the left anterior descending (LAD), right coronary artery (RCA), and left circumflex artery (LCx) using a previously validated methodology. The FAI was analyzed at a threshold of − 30 to − 190 Hounsfield units. Results FAI measurements were completed in 113 CCTAs, obtained on two same-vendor CT models. Within each CCTA, the FAI values between coronary vessels were strongly correlated (RCA and LAD R = 0.67 (p < 0.0001), RCA and LCx R = 0.58 (p < 0.0001), LAD and LCx R = 0.67 (p < 0.0001)). The FAIs of each coronary vessel between the patient’s first and last CCTA completed at 120 kV were also correlated (RCA R = 0.73 (p < 0.0001), LAD R = 0.81 (p < 0.0001), LCx R = 0.55 (p = 0.0069). Finally, a high mean FAI value of all three coronary vessels at baseline (mean ≥ − 71 HU) was predictive of cardiac mortality or re-transplantation, however, not predictive of all cause-mortality. Conclusion High baseline FAI values may identify a higher-risk cardiac transplant population; thus, FAI may support the implementation of CCTA in post-transplant surveillance. Key Point • Perivascular fat attenuation measured with coronary CT is feasible in cardiac transplant patients and may predict cardiac mortality or need for re-transplantation.

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“…Dr Suvanini Lakshmanan of the team of Matthew J Budoff in Torrance, California, USA wrote a review about the benefits of imaging and plaque analysis in serial coronary CTA for the evaluation of cardiovascular risk analysis and targeted treatment of coronary artery disease [3]. They believe that whole-heart quantification and characterization of coronary atherosclerotic plaque burden on CTA allows the transition form identifying a "vulnerable" plaque to the "vulnerable" patient.…”

Section: Introduction Topical Issue On Ct Plaque Burdenmentioning

confidence: 99%

Introduction topical issue on CT plaque burden

Reiber

2020

Int J Cardiovasc Imaging

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Comprehensive plaque assessment with serial coronary CT angiography: translation to bedside

Cited by 12 publications

References 78 publications

The Quantification of Total Coronary Atheroma Burden – A Major Step Forward

The Quantification of Total Coronary Atheroma Burden – A Major Step Forward

Evaluation of perivascular fat attenuation with coronary CT angiography in cardiac transplantation patients: an imaging biomarker candidate for prediction of cardiac mortality and re-transplantation

Introduction topical issue on CT plaque burden

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