2024
DOI: 10.3389/fchem.2024.1518110
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Comprehensive plasma metabolomics analysis of berberine treatment in ulcerative colitis rats by LC-MS/MS

Baodong Feng,
Linqi Su,
Yang Yang
et al.

Abstract: BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) influenced by multiple factors. Berberine, an isoquinoline alkaloid derived from the root and bark of Coptis chinensis Franch., has shown promise in managing UC, but its underlying mechanisms remain unclear.MethodsTo elucidate the relationship between berberine, ulcerative colitis (UC), and the organism’s metabolome, we established a dextran sulfate sodium (DSS)-induced UC model in rats. Colonic tissue was collected for histopathol… Show more

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