Comprehensive qualitative characterization of linguistic performance profiles in primary progressive aphasia: a multivariate study with FDG-PET

Catricalà, Eleonora; Santi, Gaia Chiara; Polito, Cristina; Conca, Francesca; Esposito, V.; Caminiti, Silvia Paola; Boccalini, Cecilia; Berti, Valentina; Bessi, Valentina; Marcone, Alessandra; Iannaccone, Sandro; Sorbi, Sandro; Perani, Daniela; Cappa, Stefano F.

doi:10.1016/j.neurobiolaging.2022.09.001

Cited by 5 publications

(7 citation statements)

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“…Others considered it as a hub for lexico-syntactic elaboration, pivotal for sentence comprehension [ 65 ]. In PPA patients, hypometabolism in these areas has been associated with increased WM errors in sentence comprehension and repetition [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Language assessment was based on SAND battery, which included 9 subtests [ 28 ]. The number of semantic (SEM), phonological (PHON), and working memory (WM) errors was derived from the appropriate subtests, as in Catricalà et al [ 24 , 29 ], and reported in Table 1 . Scores were then normalized for the maximum possible value (or for measures without a maximum score for the maximum values obtained by patients).…”

Section: Methodsmentioning

confidence: 99%

“…Patients were scanned using General Electric’s Medical Systems Discovery-STE scanner (in Milan) or Gemini TF PET/CT (Philips Medical Systems) (in Florence). A multi-center collection of data was already employed in a previous study of our group [ 24 , 34 ]. Considering the multi-center nature of the study (Florence/Milan), all PET images were corrected for photon attenuation, scatter, and radioactive decay and reconstructed using an Order Subset Expectation Maximization algorithm.…”

Section: Methodsmentioning

confidence: 99%

“…Conversely, svPPA shows with lexical retrieval deficit in naming task, especially in the early phase of the disease [ 22 , 23 ]. Lexical and semantic impairments may occur in both svPPA and lvPPA, probably at different stages of disease [ 24 , 25 ], and at different levels of severity, leading to a non-trivial behavioral overlap. In addition, mild impairment in auditory, verbal WM has been described in svPPA, as well as errors in sentence repetition and comprehension task [ 24 ] and in digit span [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Lexical and semantic impairments may occur in both svPPA and lvPPA, probably at different stages of disease [ 24 , 25 ], and at different levels of severity, leading to a non-trivial behavioral overlap. In addition, mild impairment in auditory, verbal WM has been described in svPPA, as well as errors in sentence repetition and comprehension task [ 24 ] and in digit span [ 12 ]. While the severity of WM deficit might be related to differences in atrophic pattern [ 12 ], the stage of the disease could play a role in the progression of WM deficit, contributing to the emergence of overlaying profiles.…”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study

Santi,

Conca,

Esposito

et al. 2024

Alz Res Therapy

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Background Primary progressive aphasia (PPA) diagnostic criteria underestimate the complex presentation of semantic (sv) and logopenic (lv) variants, in which symptoms partially overlap, and mixed clinical presentation (mixed-PPA) and heterogenous profile (lvPPA +) are frequent. Conceptualization of similarities and differences of these clinical conditions is still scarce. Methods Lexical, semantic, phonological, and working memory errors from nine language tasks of sixty-seven PPA were analyzed using Profile Analysis based on Multidimensional Scaling, which allowed us to create a distributed representation of patients’ linguistic performance in a shared space. Patients had been studied with [18F] FDG-PET. Correlations were performed between metabolic and behavioral data. Results Patients’ profiles were distributed across a continuum. All PPA, but two, presented a lexical retrieval impairment, in terms of reduced production of verbs and nouns. svPPA patients occupied a fairly clumped space along the continuum, showing a preponderant semantic deficit, which correlated to fusiform gyrus hypometabolism, while only few presented working memory deficits. Adjacently, lvPPA + presented a semantic impairment combined with phonological deficits, which correlated with metabolism in the anterior fusiform gyrus and posterior middle temporal gyrus. Starting from the shared phonological deficit side, a large portion of the space was occupied by all lvPPA, showing a combination of phonological, lexical, and working memory deficits, with the latter correlating with posterior temporo-parietal hypometabolism. Mixed PPA did not show unique profile, distributing across the space. Discussion Different clinical PPA entities exist but overlaps are frequent. Identifying shared and unique clinical markers is critical for research and clinical practice. Further research is needed to identify the role of genetic and pathological factors in such distribution, including also higher sample size of less represented groups.

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Section: Discussionmentioning

confidence: 99%