Comprehensive quantitative analysis of Chinese patent drug YinHuang drop pill by ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry

Wong, Tin-Long; An, Ya-Qi; Yan, Bing‐Chao; Yue, Rui-Qi; Zhang, Tian-Bo; Ho, Hing-Man; Ren, Tianjing; Fung, Hau-Yee; Ma, Dik‐Lung; Leung, Chung‐Hang; Liu, Zhongliang; Pu, Jian‐Xin; Han, Quan‐Bin; Sun, Han‐Dong

doi:10.1016/j.jpba.2016.04.008

Cited by 10 publications

(1 citation statement)

References 13 publications

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“…UHPLC coupled with quadrupole time‐of‐flight mass spectrometry (Q‐TOF‐MS) is a powerful technique widely applied in rapid screening of chemical components in traditional Chinese medicine, QC, and metabolism studies [11,12]. It combines the significant superiorities of UHPLC with MS technologies, such as better online separation capability, simple sample preparation, less time consumption, high selectivity, and sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Components identification and isomers differentiation in pigeon pea (Cajanus cajan L.) leaves by LC‐MS

Guo

Zhu

et al. 2021

J of Separation Science

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A valid and reliable method based on ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry using electrospray ionization was established to identify chemical constituents in the ethanol extract of pigeon pea leaves. A total of 58 compounds were detected both in positive and negative modes. Among them, 42 compounds, including 16 flavones, 1 flavonol, 5 flavanones, 9 isoflavones, 1 coumarin, 1 lactone, 6 stilbenes, 2 chalcones, and 1 other compound, were unambiguously identified or tentatively assigned in view of the retention time, the molecular formula, as well as the fragmentation patterns. Moreover, eight sets of isomers were differentiated by the ion trap mass spectrometry based on the fragment ion differences or the abundance differences of the same fragment ions. The energy‐resolved mass spectrometry in light of the relative abundance of characteristic fragment ions was adopted in the study.

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Section: Introductionmentioning

confidence: 99%