Comprehensive Reinvestigation of The Reaction of D-Aldoses With Meldrum'S Acid Yielding Mainly Chain Extended 3,6-Anhydro-2-Deoxy-Aldono-1,4-Lactones

Enantioselective Deprotonation of meso-Cycloheptanone Derivative: Application to the Synthesis of a Potential Intermediate for Pseudomonic Acid B

“…Lactone 15 was further converted into the enantiomer of the known diol 16 by hydrogenolysis over palladium hydroxide. The spectroscopic data of lactone 16 were identical with those reported . Moreover, the sign of optical rotation of our synthetic compound 16 corresponds to those of the antipode, [α] D +163.6 ( c 0.1, H 2 O) (lit …”

“…The spectroscopic data of lactone 16 were identical with those reported . Moreover, the sign of optical rotation of our synthetic compound 16 corresponds to those of the antipode, [α] D +163.6 ( c 0.1, H 2 O) (lit …”

The synthesis of d-C-mannopyranosides

“…In the same manner, Meldrum's acid has been reacted with various unprotected carbohydrates under thermodynamic conditions [223,224]. When applied to D-mannose, the major reaction product was the 3,6-anhydro-2-deoxyaldono-1,4-lactone 33, but a small amount of lactone 34 was also isolated (Scheme 74).…”

Recent Advances in Total Synthesis of Bioactive Furo[3,2‐b]furanone Natural Products

“…Gracza synthesis of (+)‐protulactone A ( 246 ) (Scheme ) started with the reaction of L ‐arabinose with Meldrum's acid to deliver the bicyclic lactone 247 . Functional group maneuvering resulted in the 2°‐OTBS protected bicyclic lactone 248 .…”