Comprehensive review of drug resistance in mammalian cancer stem cells: implications for cancer therapy
Bemrew Admassu Mengistu,
Tirunesh Tsegaw,
Yitayew Demessie
et al.
Abstract:Cancer remains a significant global challenge, and despite the numerous strategies developed to advance cancer therapy, an effective cure for metastatic cancer remains elusive. A major hurdle in treatment success is the ability of cancer cells, particularly cancer stem cells (CSCs), to resist therapy. These CSCs possess unique abilities, including self-renewal, differentiation, and repair, which drive tumor progression and chemotherapy resistance. The resilience of CSCs is linked to certain signaling pathways.… Show more
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