Comprehensive review of histone lactylation: Structure, function, and therapeutic targets

Xu, Kaiwen; Zhang, Keyi; Wang, Yanshuang; Gu, Yue

doi:10.1016/j.bcp.2024.116331

Biochemical Pharmacology

2024

DOI: 10.1016/j.bcp.2024.116331

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Comprehensive review of histone lactylation: Structure, function, and therapeutic targets

Kaiwen Xu,

Keyi Zhang,

Yanshuang Wang

et al.

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2024

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Potential Predictor of Epigenetic Age Acceleration in Men: 2D:4D Finger Pattern

Pruszkowska‐Przybylska,

Noroozi,

Rudnicka

et al. 2024

American J Hum Biol

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ObjectivesSecond to fourth digit ratio is widely known indicator of prenatal sex hormones proportion. Higher prenatal androgenization results in longer fourth finger and lower 2D:4D index. The aim of this study was to determine whether the 2D:4D digit ratio is associated with DNA methylation (DNAm) age dependently on sex.Material and MethodsThe study included 182 adults (106 females and 76 males) with a mean age of 51.5 ± 13 years. The investigation consisted of three main parts: a survey, anthropometric dimensions measurements (fingers length) and methylome analysis using collected blood samples. Genome‐wide methylation was analyzed using EPIC microarray technology. Epigenetic age and epigenetic age acceleration were calculated using several widely applied algorithms.ResultsMales with the female left hand pattern had more accelerated epigenetic age than those with the male pattern as calculated with PhenoAge and DNAmTL clocks.ConclusionsFinger female pattern 2D:4D above or equal to 1 in males is associated with epigenetic age acceleration, indicating that prenatal exposure to estrogens in males may be related to aging process in the later ontogenesis.

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Potential Predictor of Epigenetic Age Acceleration in Men: 2D:4D Finger Pattern

Pruszkowska‐Przybylska,

Noroozi,

Rudnicka

et al. 2024

American J Hum Biol

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show abstract

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Comprehensive review of histone lactylation: Structure, function, and therapeutic targets

Cited by 1 publication

References 86 publications

Potential Predictor of Epigenetic Age Acceleration in Men: 2D:4D Finger Pattern

Potential Predictor of Epigenetic Age Acceleration in Men: 2D:4D Finger Pattern

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