Comprehensive Review of Nobiletin, a Citrus Flavonoid: Metabolism and Anti-tumor Properties

Abstract

Nobiletin is a polymethoxylated flavone found in citrus peels. Thanks to its chemical structure and biological activities, nobiletin has been shown to have a positive effect on many diseases. In recent years, there has been a growing interest in research focusing on the impact of nobiletin and its metabolites on different cancer types. Nobiletin exhibits anticancer properties by impeding the proliferation of cancer cells, disrupting the cancer cell cycle, facilitating apoptosis, and regulating signaling pathways implicated in cancer development. In addition, studies have shown that its use with chemotherapeutic agents inhibits multi-drug resistance. This review aims to evaluate the metabolic properties of nobiletin and its possible effects on cancer.