Dual‐mixed refrigerant (DMR) process is a promising candidate for liquefying the natural gas (LNG) at onshore as well as offshore sites, thanks to its higher liquefaction capacity and flexibility in using full gas turbines. DMR involves two mixed refrigerant cycles to perform precooling and subcooling of natural gas (NG), and these refrigerant compositions need constant tweaking to match the ever‐changing NG cooling curve, as it is obtained from different gas fields. Mismatching of cooling curves often results in suboptimal operation, which ultimately leads to an increase in the overall energy consumption. Thus, this study is aimed at making DMR liquefaction operation close to optimal using the invasive‐weed paradigm. At first, the decision variables for performance improvement were determined using degrees of freedom analysis then through invasive‐weed paradigm the best set of parameters that results in minimal overall energy consumption were obtained. For the given set of conditions, it was found that after optimization, the DMR process can produce LNG using 16.2% less compression power compared to the published optimized DMR process. Taking into account the higher sensitivity of the DMR process against NG feed conditions, the IWO approach was also examined to find the multiple optimal solutions corresponding to different sets of feed conditions. The thermodynamic evaluation revealed that the mixed refrigerant involves in NG subcooling and interstage coolers have the highest level of exergy destruction. After successful performance improvement of the DMR process, it is also found that still, 62% improvement potential (based on avoidable/unavoidable exergy destruction analysis) is available in the DMR process that can be attained through either sole optimization or optimal retrofitting/revamping.