Comprehensive review on additives of topical dosage forms for drug delivery

Abstract

Skin is the largest organ of the human body and plays the most important role in protecting against pathogen and foreign matter. Three important modes such as topical, regional and transdermal are widely used for delivery of various dosage forms. Among these modes, the topical dosage forms are preferred because it provides local therapeutic activity when applied to the skin or mucous membranes. Additives or pharmaceutical excipients (non-drug component of dosage form) are used as inactive ingredients in dosage form or tools for structuring dosage forms. The main use of topical dosage form additives are controling the extent of absorption, maintaining the viscosity, improving the stability as well as organoleptic property and increasing the bulk of the formulation. The overall goal of this article is to provide the clinician with information related to the topical dosage form additives and their current major applications against various diseases.

An Oligodeoxynucleotide with AAAG Repeats Significantly Attenuates Burn-induced Systemic inflammatory Responses by inhibiting interferon Regulatory Factor 5 Pathway

“…In addition Data are represented as mean ± SEM (n = 3 mice/group). *P < 0.05, **P < 0.01, ***P < 0.001. required to ensure adequate localization or penetration of the topically applied AAAG ODN (43,44). In contrast, intraperitoneal application of AAAG ODN rescued the burned mice from death, suggesting that intraperitoneally applied AAAG ODN could readily reach the injured skin and blood circulation.…”

Influence of Test Parameters on Release Rate of Hydrocortisone from Cream: Study Using Vertical Diffusion Cell

“…For over a decade, researchers have envisaged delivery via a skin/topical route as an attractive arena for drug delivery. While most topical dosage forms are developed for local action, systemic delivery of drugs is achieved through transdermal systems (1,2). Drugs like scopolamine, nitroglycerin, nicotine, clonidine, fentanyl, estradiol, testosterone, lidocaine, vitamin B12, and others are delivered transdermally and have been commercially successful (3).…”

Augalinės kilmės aliejų, naudojamų pusiau kietų vaistų formų gamyboje Lietuvos vaistinėse, asortimento tyrimas

“…Kremai -tai vandeniu nuplaunamos, kosmetiniu ir estetiniu požiūriu priimtinos pusiau kietos vaistų formos. Jų sudėtyje yra viena ar daugiau vaistinių medžiagų, ištir-pinamų dažniausiai a/v tipo arba disperguotų mikrokristalinės ilgos grandinės riebalų rūgščių ar alkoholių v/a tipo dvifazėse arba daugiafazėse dispersinių sistemų emulsijose [8]. Kremai plačiai naudojami farmacijoje ir kosmetiskoje.…”