Comprehensive Review on Applications of Surfactants in Vaccine Formulation, Therapeutic and Cosmetic Pharmacy and Prevention of Pulmonary Failure due to COVID-19

Abstract

Our world is under serious threat of environmental degradation, climate change and in association with this the out breaks of diseases as pandemics. The devastating impact of the very recent COVID-19, The sharp increase in cases of Cancer, Pulmonary failure, Heart health has triggered questions for the sustainable development of pharmaceutical and medical sciences. In the search of inclusive and effective strategies to meet today’s demand, improvised methodologies and alternative green chemical, bio-based precursors are being introduced by scientists around the globe. In this extensive review we have presented the potentiality and Realtime applications of both synthetic and bio-based surfactants in bio-medical and pharmaceutical fields. For their excellent unique amphoteric nature and ability to solubilise in both organic and inorganic drugs, surfactants are one of the most potential candidates for bio-medicinal fields such as dermatology, drug delivery, anticancer treatment, surfactant therapy, vaccine formulation, personal hygiene care and many more. The self-assembly property of surfactants is a very powerful function for drug delivery systems that increases the bio-availability of the poorly aqueous soluble pharmaceutical products by influencing their solubility. Over the decades many researchers have reported the antimicrobial, anti-adhesive, antibiofilm, anti-inflammatory, antioxidant activities of surfactants regarding its utility in medicinal purposes. In some reports surfactants are found to have spermicidal and laxative activity too. This comprehensive report is targeted to enlighten the versatile applications of Surfactants in drug delivery, vaccine formulation, Cancer Treatment, Therapeutic and cosmetic Pharmaceutical Sciences and prevention of pulmonary failure due to COVID-19.

Diverse utilization of surfactants in coal-floatation for the sustainable development of clean coal production and environmental safety: a review

“…However, despite their effectiveness, they also induce some negative environmental effects. 63 Biosurfactants (rhamnolipids, sophorolipids, and lipopeptides) [64][65][66][67] possess lower toxicity than synthetic surfactants and can be used as a good oating agent. 63 Surfactin is a lipopeptide that is produced by Bacillus subtilis, exhibiting excellent otation properties.…”

A comprehensive review on production of bio-surfactants by bio-degradation of waste carbohydrate feedstocks: an approach towards sustainable development

“…14–17 Thus bio-surfactant itself and its production process obeys the principles of green chemistry. 18,19 More recently the bio-medical advantages of these BSs in drug design and delivery have been reported by B. Das et al 20 Hence, in recent days these BSs are becoming popular in biotechnology products for industrial and pharmaceutical applications. Bio-surfactants are proved to be extensively useful as emulsifiers, de-emulsifiers, wetting and foaming agents, edible food additives, cosmetics and detergents in house hold goods.…”

Dual-Emission Single Sensing Element-Assembled Fluorescent Sensor Arrays for the Rapid Discrimination of Multiple Surfactants in Environments

“…Under the background of coexistence of coronavirus disease-19 (COVID-19) and human beings, surfactants are usually added into disinfectants to provide a synergistic effect with alcohols to inactivate the coronavirus. − However, the extensive use of disinfectants usually leads to the release of surfactants into the ecosystem, resulting in a series of environmental issues. In addition, exposure to surfactants with high concentrations can cause adverse health effects, such as irritation to human eyes and the skin. − In recent years, environmental health problems caused by surfactants have received extensive attention. − To date, many instrumental methods for surfactant detection have been developed, , but these techniques were hampered in wide applications due to high cost, tedious procedures, and time-consuming analysis. , Thus, it is essential to explore simple, efficient, and high-throughput methods to detect environmental surfactants for risk assessment.…”