Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs

Chauhan, Aditi; Kumar, Manoj; Kumar, Awanish; Kanchan, K C

doi:10.1016/j.lfs.2021.119301

Cited by 38 publications

(34 citation statements)

References 297 publications

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“…[4] Some of the oldest and most well-known TB drug targets include enoyl-acyl carrier protein reductase (InhA), ATP synthetase, and RNA polymerase binding protein (RbpA). [5][6][7] The full mechanisms of targeting these enzymes are still not fully understood and additional research is also required to explain how M. tuberculosis developed resistance. Multidrug resistant (MDR) strains of TB affecting the efficacy of rifampicin and isoniazid, two first-line antibiotics in the treatment of the disease, have emerged.…”

Section: Introductionmentioning

confidence: 99%

Indole‐3‐Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target

2021

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Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis, affects millions of people worldwide. Several TB drugs have lost efficacy due to emerging drug resistance and new anti-TB targets are needed. Recent research suggests that indole-3-glycerol phosphate synthase (IGPS) in M. tuberculosis (MtIGPS) could be such a target. IGPS is a (β/α) 8 -barrel enzyme that catalyzes the conversion of 1-(o-carboxyphenylamino)-1deoxyribulose 5'-phosphate (CdRP) into indole-glycerolphosphate (IGP) in the bacterial tryptophan biosynthetic path-way. M. tuberculosis over expresses the tryptophan pathway genes during an immune response and inhibition of MtIGPS allows CD4 T-cells to more effectively fight against M. tuberculosis. Here we review the published data on MtIGPS expression, kinetics, mechanism, and inhibition. We also discuss MtIGPS crystal structures and compare them to other IGPS structures to reveal potential structure-function relationships of interest for the purposes of drug design and biocatalyst engineering.

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Section: Introductionmentioning

confidence: 99%

Indole‐3‐Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target

2021

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“…Drug-resistant TB continues to be a public health threat. [2] In 2019, close to half a million people developed rifampin-resistant TB, of which 78 % had multidrug-resistant (MDR) TB. With the development of drug resistance, the treatment of TB is becoming more and more difficult.…”

Section: Introductionmentioning

confidence: 99%

“…Estimated 10.0 million people suffered from TB in 2019 globally. Drug‐resistant TB continues to be a public health threat [2] . In 2019, close to half a million people developed rifampin‐resistant TB, of which 78 % had multidrug‐resistant (MDR) TB.…”

Section: Introductionmentioning

confidence: 99%

Synergetic Effect of Rifampin Loaded Mussel‐Inspired Silver Nanoparticles for Enhanced Antibacterial Activity Against Multidrug‐Resistant Strain of Mycobacterium Tuberculosis

et al. 2021

ChemistrySelect

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Tuberculosis (TB) is among the top ten causes of death worldwide. The emergence of multidrug-resistant (MDR) TB has been challenging to cure TB patients and control the airborne transmission. To ensure the effectiveness of rifampin (RF) in the treatment of MDR TB infection, new and safe silver nanoparticles were used in combination. In this study, polydopamine decorated silver nanoparticles (Ag-PDA NPs) were synthesized under mild conditions in which antituberculosis drug RF was loaded. Subsequently, the antibacterial activity of different ratios of Ag-PDA NPs/RF against MDR strains of Mycobacterium tuberculosis (M. tuberculosis) was evaluated by minimum inhibitory concentration (MIC) tests. MIC results showed a synergistic interaction between Ag-PDA NPs and RF, and the optimal antibacterial effect against MDR strain of M. tuberculosis was at the mass ratio of 2 Ag-PDA NPs : 8RF. In addition, RF loaded Ag-PDA NPs (RF@Ag-PDA NPs) were constructed and characterized. The results indicated that RF@Ag-PDA NPs might be considered as promising nano drugs to inhibit the growth of MDR strain of M. tuberculosis and keep the potency of RF in clinical practice.

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“…Mycobacterium tuberculosis (MBTC) is responsible for the development of tuberculosis, a potentially fatal respiratory disease that also can cause extrapulmonary disease (e.g., of the urinary system). MBTC is increasingly becoming more difficult to treat due to antibiotic resistance ( 122 ). In a rat peripheral blood mononuclear cell model, administration of high concentrations of IgY anti-MBTC increased interleukin-2 and interferon expression ( 123 ).…”

Section: Treatment Of Bacterial Infectionsmentioning

confidence: 99%

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

et al. 2021

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Antiviral, antibacterial, and antiparasitic drugs and vaccines are essential to maintaining the health of humans and animals. Yet, their production can be slow and expensive, and efficacy lost once pathogens mount resistance. Chicken immunoglobulin Y (IgY) is a highly conserved homolog of human immunoglobulin G (IgG) that has shown benefits and a favorable safety profile, primarily in animal models of human infectious diseases. IgY is fast-acting, easy to produce, and low cost. IgY antibodies can readily be generated in large quantities with minimal environmental harm or infrastructure investment by using egg-laying hens. We summarize a variety of IgY uses, focusing on their potential for the detection, prevention, and treatment of human and animal infections.

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Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs

Cited by 38 publications

References 297 publications

Indole‐3‐Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target

Indole‐3‐Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target

Synergetic Effect of Rifampin Loaded Mussel‐Inspired Silver Nanoparticles for Enhanced Antibacterial Activity Against Multidrug‐Resistant Strain of Mycobacterium Tuberculosis

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

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