Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent

Rauf, Abdur; Shariati, Mohammad Ali; Imran, Muhammad; Bashir, Kashif; Khan, Shahid Ali; Mitra, Saikat; Emran, Talha Bin; Badalova, Kamala; Mubarak, Mohammad S.; Aljohani, Abdullah S. M.; Alhumaydhi, Fahad A.; Дерхо, М.А.; Korpayev, Serdar; Zengin, Gökhan

doi:10.1007/s11356-022-18754-6

Cited by 63 publications

(34 citation statements)

References 135 publications

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“…In various studies, flavonoids were found to be capable of demonstrating strong anticancer effects by acting as antioxidants; modulating ROS-scavenging enzyme activity; upregulating apoptosis, autophagy and cell cycle arrest; and downregulating inflammation, proliferation processes and metastasis formation [ 8 , 9 , 10 , 11 , 12 , 13 ]. Naringin and naringenin, which belong to a subclass of flavonoids known as flavanones, are the main bioactive compounds in citrus fruits, and they are known for their beneficial effects on human health, which have been summarized in several recent reviews [ 4 , 14 , 15 , 16 , 17 , 18 ]. However, the mechanisms of the anticancer effects of naringin and naringenin have not yet been fully clarified, and they are under extensive investigation.…”

Section: Introductionmentioning

confidence: 99%

Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Stabrauskiene

Kopustinskienė²,

Lažauskas³

et al. 2022

Biomedicines

120

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Naringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption of which is beneficial for human health and has been practiced since ancient times. Numerous studies have reported these substances’ antioxidant and antiandrogenic properties, as well as their ability to protect from inflammation and cancer, in various in vitro and in vivo experimental models in animals and humans. Naringin and naringenin can suppress cancer development in various body parts, alleviating the conditions of cancer patients by acting as effective alternative supplementary remedies. Their anticancer activities are pleiotropic, and they can modulate different cellular signaling pathways, suppress cytokine and growth factor production and arrest the cell cycle. In this narrative review, we discuss the effects of naringin and naringenin on inflammation, apoptosis, proliferation, angiogenesis, metastasis and invasion processes and their potential to become innovative and safe anticancer drugs.

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Section: Introductionmentioning

confidence: 99%

Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Stabrauskiene

Kopustinskienė²,

Lažauskas³

et al. 2022

Biomedicines

120

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“…Anticancer effects have been observed in many plant species, especially in plants that have been utilized in traditional herbal treatments used in developing countries ( Greenwell and Rahman, 2015 ). It is estimated that dietary modifications could prevent nearly one-third of current cancer cases ( Brennan et al, 2010 ; Rastegari and Rafieian-Kopaei, 2016 ; Rauf et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential

et al. 2022

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Cancer is a life-threatening disease caused by the uncontrolled division of cells, which culminates in a solid mass of cells known as a tumor or liquid cancer. It is the leading cause of mortality worldwide, and the number of cancer patients has been increasing at an alarming rate, with an estimated 20 million cases expected by 2030. Thus, the use of complementary or alternative therapeutic techniques that can help prevent cancer has been the subject of increased attention. Garlic, the most widely used plant medicinal product, exhibits a wide spectrum of biological activities, including antibacterial, hypo-lipidemic, antithrombotic, and anticancer effects. Diallyl disulfide (DADS) is a major organosulfur compound contained within garlic. Recently, several experimental studies have demonstrated that DADS exhibits anti-tumor activity against many types of tumor cells, including gynecological cancers (cervical cancer, ovarian cancer), hematological cancers (leukemia, lymphoma), lung cancer, neural cancer, skin cancer, prostate cancer, gastrointestinal tract and associated cancers (esophageal cancer, gastric cancer, colorectal cancer), hepatocellular cancer cell line, etc. The mechanisms behind the anticancer action of DADS include epithelial-mesenchymal transition (EMT), invasion, and migration. This article aims to review the available information regarding the anti-cancer potential of DADS, as well as summarize its mechanisms of action, bioavailability, and pharmacokinetics from published clinical and toxicity studies.

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“…One of the most vital utilizations of plant-derived therapeutics formed by phenols is for preventing cancer and chemotherapy. Polyphenols can decline the growth rate of tumors, thus having an anti-cancer effect [ 107 , 108 , 109 ]. The anti-cancer mechanism has been reported by Terry [ 110 ], whereby chemoprevention impacts polyphenols such as antioxidants, reducing free radicals and ROS, thus decreasing their damaging effects on DNA.…”

Section: Health Benefits and Risks Of Lettucementioning

confidence: 99%

Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce—A Comprehensive Review

Shi

et al. 2022

Antioxidants

Self Cite

101

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Lettuce is one of the most famous leafy vegetables worldwide with lots of applications from food to other specific uses. There are different types in the lettuce group for consumers to choose from. Additionally, lettuce is an excellent source of bioactive compounds such as polyphenols, carotenoids, and chlorophyll with related health benefits. At the same time, nutrient composition and antioxidant compounds are different between lettuce varieties, especially for green and red lettuce types. The benefit of lettuce consumption depends on its composition, particularly antioxidants, which can function as nutrients. The health benefits rely on their biochemical effect when reaching the bloodstream. Some components can be released from the food matrix and altered in the digestive system. Indeed, the bioaccessibility of lettuce is measuring the quantity of these compounds released from the food matrix during digestion, which is important for health-promoting features. Extraction of bioactive compounds is one of the new trends observed in lettuce and is necessarily used for several application fields. Therefore, this review aims to demonstrate the nutritional value of lettuce and its pharmacological properties. Due to their bioaccessibility and bioavailability, the consumer will be able to comprehensively understand choosing a healthier lettuce diet. The common utilization pattern of lettuce extracted nutrients will also be summarized for further direction.

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Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent

Cited by 63 publications

References 135 publications

Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential

Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce—A Comprehensive Review

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