Comprehensive SNP Scan of DNA Repair and DNA Damage Response Genes Reveal Multiple Susceptibility Loci Conferring Risk to Tobacco Associated Leukoplakia and Oral Cancer

Mondal, Prasenjit; Datta, Sayantan; Maiti, Guru Prasad; Baral, Aradhita; Jha, Ganga Nath; Panda, Chinmay Kumar; Chowdhury, Shantanu; Ghosh, Saurabh; Roy, Bidyut; Roychoudhury, Susanta

doi:10.1371/journal.pone.0056952

Cited by 28 publications

(20 citation statements)

References 62 publications

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“…Genetic polymorphisms of MMR genes in patients affected by OSCC were also investigated, and some studies showed that single nucleotide polymorphism (SNP) of hMLH1 and hMSH3 can be associated with OSCC predisposition . Nogueira et al showed that inherited hMLH1 c.‐93G>A, hMSH2 c.21119C>G, hMSH3 c.3133G>A, and EXO1 c.1765G>A polymorphisms are predictors of clinical outcomes of patients affected by HNSCC.…”

Section: Mmr Expression In Oral Squamous Cell Carcinomamentioning

confidence: 99%

Mismatch repair system proteins in oral benign and malignant lesions

Amaral‐Silva

Martins

Pontes

et al. 2016

J Oral Pathology Medicine

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Different environmental agents may cause DNA mutations by disrupting its double-strand structure; however, even normal DNA polymerase function may synthesize mismatch nucleotide bases, occasionally demonstrating failure in its proofreading activity. To overcome this issue, mismatch repair (MMR) system, a group of proteins specialized in finding mispairing bases and small loops of insertion or deletion, works to avoid the occurrence of mutations that could ultimately lead to innumerous human diseases. In the last decades, the role of MMR proteins in oral carcinogenesis and in the development of other oral cavity neoplasms has grown, but their importance in the pathogenesis and their prognostic potential for patients affected by oral malignancies, especially oral squamous cell carcinoma (OSCC), remain unclear. Therefore, in this manuscript we aimed to review and critically discuss the currently available data on MMR proteins expression in oral potentially malignant lesions, in OSCC, and in other oral neoplasms to better understand their relevance in these lesions.

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Section: Mmr Expression In Oral Squamous Cell Carcinomamentioning

confidence: 99%

Mismatch repair system proteins in oral benign and malignant lesions

Amaral‐Silva

Martins

Pontes

et al. 2016

J Oral Pathology Medicine

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“…[6–10] Neoplastic and preneoplastic conditions take a particular attention among oral diseases induced by tobacco smoking, because of the importance that early diagnosis can have with such clinical pictures. [11] Cigarettes smoking is also one of the most important known cofactor in the development of oral leukoplakia, [12] palatal leukokeratosis and melanosis, [13] and of the modifications of the oral microenvironment which can lead to several opportunistic pathologies, such as oral candidiasis and hairy tongue. [14] Furthermore, tobacco smoking represents a high risk factor for periodontal diseases, [15] enhancing the loss of gingival attachment, [16] and the increase of gingival regression, [17] with the final result of a severe progression of periodontal inflammation.…”

Section: Introductionmentioning

confidence: 99%

Crosstalk between oral and general health status in e-smokers

Tatullo¹,

Gentile²,

Paduano³

et al. 2016

Medicine

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Electronic cigarette (e-cigarette) simulates the act of tobacco smoking by vaporizing a mixture of propylene glycol, nicotine, and flavoring agents. e-cigarette has been proposed as a product able to aid to stop smoking. The aim of the study is to verify the clinical variations of periodontal health induced by e-cigarettes use and, moreover, to investigate about the awareness of the e-smokers about their health variations and about their hypothetical need to turn back to smoke combustible cigarettes.This clinical observational pilot study involved 110 out of 350 smokers, who switched to e-cigarette. Patients were subjected to oral examinations. A questionnaire to self-assess the variations of some parameters of general health, and to self-assess the need to smoke combustible cigarettes, was distributed to such subjects involved in the study.At the end of the study, we registered a progressive improvement in the periodontal indexes, as well as in the general health perception. Finally, many patients reported an interesting reduction in the need to smoke.In the light of this pilot study, the e-cigarette can be considered as a valuable alternative to tobacco cigarettes, but with a positive impact on periodontal and general health status.

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“…1,3 Despite new treatment modalities such as radiotherapy and chemotherapy, HNSCC is associated with high rates of recurrence and mortality, with 5-year survival rates of approximately 50%. 4 Therefore details of the genetic and epigenetic events leading to development of HNSCC should be analyzed to help design novel diagnostic and therapeutic procedures that can be used in the clinical management of the disease.…”

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confidence: 99%