Comprehensive study of Anthriscus sylvestris lignans

Orčić, Dejan; Berežni, Sanja; Škorić, Dušan; Mimica–Dukić, Neda

doi:10.1016/j.phytochem.2021.112958

Cited by 18 publications

(9 citation statements)

References 61 publications

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“…Within each subgroup, lignans exhibit considerable variations in the oxidation levels of both the aromatic rings and propyl side chains [ 72 ]. In A. sylvestris , dibenzylbutyrolactone and aryltetralin lignans are the most prevalent [ 73 ].…”

Section: Lignan Structurementioning

confidence: 99%

“…In addition to the dibenzylbutyrolactones shown in Table 1 , A. sylvestris also contains various hydroxy- and oxo-dibenzylbutyrolactones, as well as unsaturated dibenzylbutyrolactones, detailed in Table 2 and Table 3 . These lignans were primarily identified in A. sylvestris by our research group [ 73 ].…”

Section: Lignan Structurementioning

confidence: 99%

“…Their main structural difference lies in the composition of the B ring, which can be either a cyclohexane ring in aryltetralins or a benzene ring in arylnaphtalenes [ 76 ]. The representative arylnaphthalene found in A. sylvestris is tetradehydropodophyllotoxin [ 73 ].…”

Section: Lignan Structurementioning

confidence: 99%

“…Additionally, other classes are present in A. sylvestris , with representatives such as phylligenin (tetrahydrofurofuran) [ 26 ], lariciresinol [ 53 ] and 9-acetoxy-7′-oxo-3,3′,4,4′-tetramethoxy-7,9′-epoxylignan (tetrahydrofurans) [ 73 ], and secoisolariciresinol [ 53 , 73 , 77 ] and 3,4,4′-trimethoxy-lignan-9,9′-diol (dibenzylbutandiols) [ 73 ]. Their structures are given in Figure 1 .…”

Section: Lignan Structurementioning

confidence: 99%

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Anthriscus sylvestris—Noxious Weed or Sustainable Source of Bioactive Lignans?

Berežni,

Mimica-Dukić,

Domina

et al. 2024

Plants

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Anthriscus sylvestris (L.) Hoffm. (Apiaceae), commonly known as wild chervil, has gained scientific interest owing to its diverse phytochemical profile and potential therapeutic applications. The plant, despite being categorized as a noxious weed, is traditionally used in treating various conditions like headaches, dressing wounds, and as a tonic, antitussive, antipyretic, analgesic, and diuretic. Its pharmacological importance stems from containing diverse bioactive lignans, especially aryltetralins and dibenzylbutyrolactones. One of the main compounds of A. sylvestris, deoxypodophyllotoxin, among its wide-ranging effects, including antitumor, antiproliferative, antiplatelet aggregation, antiviral, anti-inflammatory, and insecticidal properties, serves as a pivotal precursor to epipodophyllotoxin, crucial in the semisynthesis of cytostatic agents like etoposide and teniposide. The main starting compound for these anticancer medicines was podophyllotoxin, intensively isolated from Sinopodophyllum hexandrum, now listed as an endangered species due to overexploitation. Since new species are being investigated as potential sources, A. sylvestris emerges as a highly promising candidate owing to its abundant lignan content. This review summarizes the current knowledge on A. sylvestris, investigating its biological and morphological characteristics, and pharmacological properties. Emphasizing the biological activities and structure–activity relationship, this review underscores its therapeutic potential, thus encouraging further exploration and utilization of this valuable plant resource.

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Section: Lignan Structurementioning

confidence: 99%

Section: Lignan Structurementioning

confidence: 99%

Section: Lignan Structurementioning

confidence: 99%

Section: Lignan Structurementioning

confidence: 99%

See 2 more Smart Citations

Anthriscus sylvestris—Noxious Weed or Sustainable Source of Bioactive Lignans?

Berežni,

Mimica-Dukić,

Domina

et al. 2024

Plants

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“…To identify the active compounds responsible for proteasomal activation, we fractionated and purified JBE and finally isolated two compounds (Figure 4). After predicting the structures of the isolated compounds from mass spectrometry and nuclear magnetic resonance data, the final structures were identified via a comparison of data presented in previous reports [27,28].…”

Section: Anthricin and Yatein Are Compounds Responsible For The Prote...mentioning

confidence: 99%

Juniper berry extract containing Anthricin and Yatein suppresses lipofuscin accumulation in human epidermal keratinocytes through proteasome activation, increases brightness and decreases spots in human skin

Sakamoto,

Fujimoto,

Nakagawa

et al. 2023

Intern J of Cosmetic Sci

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ObjectiveSkin brightness and spot have a significant impact on youthful and beautiful appearance. One important factor influencing skin brightness is the amount of internal reflected light from the skin. Observers recognize the total surface‐reflected light and internal reflected light as skin brightness. The more internal reflected light from the skin, the more attractive and brighter the skin appears. This study aims to identify a new natural cosmetic ingredient that increases the skin's internal reflected light, decreases spot and provides a youthful and beautiful skin appearance.MethodsLipofuscin in epidermal keratinocytes, the aggregating complex of denatured proteins and peroxidized lipids, is one factor that decreases skin brightness and causes of spot. Aggregates block light transmission, and peroxidized lipids lead to skin yellowness, dullness and age spot. Lipofuscin is known to accumulate intracellularly with ageing. Rapid removal of intracellular denatured proteins prevents lipofuscin formation and accumulation in cells. We focused a proteasome system that efficiently removes intracellular denatured proteins. To identify natural ingredients that increase proteasome activity, we screened 380 extracts derived from natural products. The extract with the desired activity was fractionated and purified to identify active compounds that lead to proteasome activation. Finally, the efficacy of the proteasome‐activating extract was evaluated in a human clinical study.ResultsWe discovered that Juniperus communis fruits (Juniper berry) extract (JBE) increases proteasome activity and suppresses lipofuscin accumulation in human epidermal keratinocytes. We found Anthricin and Yatein, which belong to the lignan family, to be major active compounds responsible for the proteasome‐activating effect of JBE. In a human clinical study, an emulsion containing 1% JBE was applied to half of the face twice daily for 4 weeks, resulting in increased internal reflected light, brightness improvement (L‐value) and reduction in yellowness (b‐value) and spot in the cheek area.ConclusionThis is the first report demonstrating that JBE containing Anthricin and Yatein decreases lipofuscin accumulation in human epidermal keratinocytes through proteasome activation, increases brightness and decreases surface spots in human skin. JBE would be an ideal natural cosmetic ingredient for creating a more youthful and beautiful skin appearance with greater brightness and less spot.

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