Comprehensive study of clinicopathological and immune cell infiltration and lactate dehydrogenase expression in patients with thymic epithelial tumours

Ying, Jianghua; Huang, Yueyu; Ye, Xuemei; Zhang, Yimin; Yao, Qifeng; Wang, Jiahui; Yang, Xuping; Yu, Chang; Guo, Yangzhong; Zhang, Xiaofang; Lv, Qiaoli; Wang, Changchun; Mao, Weimin; Zhao, An

doi:10.1016/j.intimp.2023.111205

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Circumstantial evidence that THs, especially the aggressive types, show profound changes in their metabolism comes from nuclear medicine and positron emission tomography (PET) studies using fluorodeoxyglucose. It has been shown that high preoperative glucose uptake [ 101 , 102 ] and high serum levels of lactate dehydrogenase (LDH) [ 103 ] can be used to predict histologic subtypes and prognosis in thymoma patients. These observations were consistent with a metabolic study in THs showing high lactic acid and glutamine levels and activation of the proline/arginine, glycolysis, and glutathione pathways, suggesting increased glycolysis and glutaminolysis [ 104 ].…”

Section: Metabolic Reprogramming In Thymomasmentioning

confidence: 99%

Non-Mutational Key Features in the Biology of Thymomas

Küffer,

Müller,

Marx

et al. 2024

Cancers

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Thymomas (THs) are a unique group of heterogeneous tumors of the thymic epithelium. In particular, the subtypes B2 and B3 tend to be aggressive and metastatic. Radical tumor resection remains the only curative option for localized tumors, while more advanced THs require multimodal treatment. Deep sequencing analyses have failed to identify known oncogenic driver mutations in TH, with the notable exception of the GTF2I mutation, which occurs predominantly in type A and AB THs. However, there are multiple alternative non-mutational mechanisms (e.g., perturbed thymic developmental programs, metabolism, non-coding RNA networks) that control cellular behavior and tumorigenesis through the deregulation of critical molecular pathways. Here, we attempted to show how the results of studies investigating such alternative mechanisms could be integrated into a current model of TH biology. This model could be used to focus ongoing research and therapeutic strategies.

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Section: Metabolic Reprogramming In Thymomasmentioning

confidence: 99%

Non-Mutational Key Features in the Biology of Thymomas

Küffer,

Müller,

Marx

et al. 2024

Cancers

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Anti‑epileptic mechanism of isopimaric acid from Platycladi cacumen based on network pharmacology, molecular docking and biological validation

Wang,

et al. 2024

Exp Ther Med

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Platycladi cacumen (PC) is derived from the dry twigs and leaves of Platycladi orientalis (L.) Franco and exerts anti-epileptic effects. However, its mechanism of action remains unknown. The present study explored the potential anti-epileptic components and mechanisms of PC. The primary active components and targets of PC were analyzed using network pharmacology and a lipopolysaccharide (LPS)-induced murine microglial cell line (BV2) was used to confirm anti-epileptic effects by detecting reactive oxygen species (ROS), apoptosis, inflammatory markers, cell migration and signaling pathways. A total of 13 core active components showed druggable properties, of which deoxypicrop odophyllotoxin, hinokinin and isopimaric acid (IPA) were predicted to cross the blood-brain barrier. In total, 255 potential targets of these three compounds were predicted using SwissTargetPrediction and Similarity Ensemble Approach websites and 150 were associated with epilepsy. In vitro experiments confirmed that IPA significantly inhibited LPS-induced microglial oxidative stress and inflammation by decreasing the migration area, cellular ROS content, lactate dehydrogenase release and early phase of apoptosis. IPA also increased the mRNA expression of anti-oxidative enzymes (superoxide dismutase-1 and -2) and suppressed inflammatory cytokines (interleukin-1β and tumor necrosis factor-α). Furthermore, IPA phosphorylated AKT and mTOR proteins. Taken together, the present findings suggested that IPA is a potential anti-epileptic compound derived from PC.

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Comprehensive study of clinicopathological and immune cell infiltration and lactate dehydrogenase expression in patients with thymic epithelial tumours

Cited by 2 publications

References 43 publications

Non-Mutational Key Features in the Biology of Thymomas

Non-Mutational Key Features in the Biology of Thymomas

Anti‑epileptic mechanism of isopimaric acid from Platycladi cacumen based on network pharmacology, molecular docking and biological validation

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