Comprehensive study to investigate the role of various aminoglycoside resistance mechanisms in clinical isolates of Acinetobacter baumannii

Sheikhalizadeh, Vajihe; Hasani, Alka; Rezaee, Mohammad Ahangarzadeh; Rahmati-Yamchi, Mohammad; Hasani, Akbar; Ghotaslou, Reza; Goli, Hamid Reza

doi:10.1016/j.jiac.2016.09.012

Cited by 43 publications

(35 citation statements)

References 28 publications

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“…The majority of the isolates (97.2%) that harbored the aph(3´)-VI gene displayed resistance to amikacin ( Table 1); the high frequency of amikacin inactivation by this enzyme has been previously described 14 . Among the 28 isolates that harbored the gentamicin resistance gene aac(3)-Ia, 85% were resistant to gentamicin, suggesting the production of the AAC(3)-Ia enzyme in these isolates.…”

Section: -Likementioning

confidence: 69%

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Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

Santi

Casella

Tolentino

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). Methods: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. Results: The key genes found were bla OXA-51like, the association ISAba1-bla OXA-23-like , and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. Conclusions: The dissemination of bla OXA-23-like and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.

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Section: -Likementioning

confidence: 69%

“…The production of AMEs is the most important aminoglycoside resistance mechanism in A. baumannii 3 . In this study, four AME genes were found, and two of them, aph(3´)-VI and aac(6´)-Ib, are known to be responsible for amikacin resitance 14 .…”

Section: -Likementioning

confidence: 79%

Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

Santi

Casella

Tolentino

et al. 2020

Rev. Soc. Bras. Med. Trop.

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show abstract

“…Unlike AMEs, methylases induce high-level resistance across all clinically useful aminoglycosides, including gentamicin, tobramycin, and amikacin [198]. The armA gene is found among other Gram-negative organisms, is plasmid-borne, and lies within a transposon (Tn1548) [202].…”

Section: Aminoglycosidesmentioning

confidence: 99%

“…Efflux pump overactivity RND pump AdeABC, AdeIJK, and AcrAB-TolC [179][180][181][182][183][184][185] Tet pump TetA and TetB [180] Ribosomal protection Tetracycline dissociation from ribosome Tet(O) and Tet(M) [180,[186][187][188] Fluoroquinolones Target mutation DNA gyrase GyrA [191,192] DNA topoisomerase IV ParC [191,192] Efflux pump overactivity RND pump AdeABC [81,191] MATE family AbeM [194] Aminoglycosides Drug inactivating enzymes Aminoglycoside modifying enzymes AAC(3)-Ia [185] AAC(3 )-Ia [200] ANT(2 )-Ia [200] ANT(3")-Ia [199] Target mutation 16sRNA methylase genes armA, rmtA, rmtB, rmtC, and rmtD [197,201] Efflux pump overactivity RND pumps AdeABC [175,202] Macrolides Efflux pump overactivity SMR pump AbeS [204] Polymyxins…”

Section: Tertacyclinesmentioning

confidence: 99%

Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen

2020

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Being a multidrug-resistant and an invasive pathogen, Acinetobacter baumannii is one of the major causes of nosocomial infections in the current healthcare system. It has been recognized as an agent of pneumonia, septicemia, meningitis, urinary tract and wound infections, and is associated with high mortality. Pathogenesis in A. baumannii infections is an outcome of multiple virulence factors, including porins, capsules, and cell wall lipopolysaccharide, enzymes, biofilm production, motility, and iron-acquisition systems, among others. Such virulence factors help the organism to resist stressful environmental conditions and enable development of severe infections. Parallel to increased prevalence of infections caused by A. baumannii, challenging and diverse resistance mechanisms in this pathogen are well recognized, with major classes of antibiotics becoming minimally effective. Through a wide array of antibiotic-hydrolyzing enzymes, efflux pump changes, impermeability, and antibiotic target mutations, A. baumannii models a unique ability to maintain a multidrug-resistant phenotype, further complicating treatment. Understanding mechanisms behind diseases, virulence, and resistance acquisition are central to infectious disease knowledge about A. baumannii. The aims of this review are to highlight infections and disease-producing factors in A. baumannii and to touch base on mechanisms of resistance to various antibiotic classes.

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“…Wen et al, (2014), Sheikhalizadeh et al, (2017) and Heidary et al, (2017). Different results were obtained by Zhou et al, (2010) …”

Section: Effects Of Aminoglycosides Combinationsmentioning

confidence: 96%

Aminoglycosides Resistance among Acinetobacter baumannii Complex Isolated from Hospital Acquired Blood Stream Infections

Mashaly¹

2017

Int.J.Curr.Microbiol.App.Sci

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Comprehensive study to investigate the role of various aminoglycoside resistance mechanisms in clinical isolates of Acinetobacter baumannii

Cited by 43 publications

References 28 publications

Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen

Aminoglycosides Resistance among Acinetobacter baumannii Complex Isolated from Hospital Acquired Blood Stream Infections

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