Comprehensive Subcellular Localization of Swine Acute Diarrhea Syndrome Coronavirus Proteins

Yuan, Cong; Suo, Xuepeng; Duan, Yueyue; Li, Xiangtong; Shi, Lei; Cao, Liyan; Kong, Xiangyu; Zheng, Haixue; Wang, Qi

doi:10.1128/jvi.00772-22

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Enzymatically cleaved non-structural proteins can co-localize with the Golgi, endoplasmic reticulum, nucleus, and microtubule proteins, indicating their functional diversity in various cellular processes. For example, nsp9 co-localizes with microtubule proteins, suggesting its potential involvement in cellular morphological alterations following SADS-CoV infection [45] (Figure 3).…”

Section: Structure Of the Swine Acute Diarrhea Syndrome Coronavirus (...mentioning

confidence: 99%

“…Coronavirus envelope proteins are important for increasing the membrane permeability to ions and are involved in viral morphogenesis and assembly [76,77]. These findings have led to the conclusion that the maturation of SADS-CoV occurs in late endosomes [45,78,79]. The coronavirus spike glycoprotein (S) comprises the S1 and S2 subunits [46].…”

Section: Structure Of the Swine Acute Diarrhea Syndrome Coronavirus (...mentioning

confidence: 99%

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Research Advances on Swine Acute Diarrhea Syndrome Coronavirus

Liu,

Huang,

et al. 2024

Animals

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Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a virulent pathogen that causes acute diarrhea in piglets. The virus was first discovered in Guangdong Province, China, in 2017 and has since emerged in Jiangxi, Fujian, and Guangxi Provinces. The outbreak exhibited a localized and sporadic pattern, with no discernable temporal continuity. The virus can infect human progenitor cells and demonstrates considerable potential for cross-species transmission, representing a potential risk for zoonotic transmission. Therefore, continuous surveillance of and comprehensive research on SADS-CoV are imperative. This review provides an overview of the temporal and evolutionary features of SADS-CoV outbreaks, focusing on the structural characteristics of the virus, which serve as the basis for discussing its potential for interspecies transmission. Additionally, the review summarizes virus–host interactions, including the effects on host cells, as well as apoptotic and autophagic behaviors, and discusses prevention and treatment modalities for this viral infection.

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Section: Structure Of the Swine Acute Diarrhea Syndrome Coronavirus (...mentioning

confidence: 99%

Section: Structure Of the Swine Acute Diarrhea Syndrome Coronavirus (...mentioning

confidence: 99%

Research Advances on Swine Acute Diarrhea Syndrome Coronavirus

Liu,

Huang,

et al. 2024

Animals

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Subcellular localization of viral proteins after porcine epidemic diarrhea virus infection and their roles in the viral life cycle

Chen,

Cai,

Liang

et al. 2024

International Journal of Biological Macromolecules

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Comprehensive Subcellular Localization of Swine Acute Diarrhea Syndrome Coronavirus Proteins

Abstract: SADS-CoV is the first documented spillover of a bat coronavirus that causes severe diseases in domestic animals. Our study is an in-depth annotation of the newly discovered swine coronavirus SADS-CoV genome and viral protein expression.

Cited by 2 publications

References 37 publications

Research Advances on Swine Acute Diarrhea Syndrome Coronavirus

Research Advances on Swine Acute Diarrhea Syndrome Coronavirus

Subcellular localization of viral proteins after porcine epidemic diarrhea virus infection and their roles in the viral life cycle

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